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    CDT1 chromatin licensing and DNA replication factor 1 [ Homo sapiens (human) ]

    Gene ID: 81620, updated on 3-Dec-2023

    Summary

    Official Symbol
    CDT1provided by HGNC
    Official Full Name
    chromatin licensing and DNA replication factor 1provided by HGNC
    Primary source
    HGNC:HGNC:24576
    See related
    Ensembl:ENSG00000167513 MIM:605525; AllianceGenome:HGNC:24576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUP; RIS2
    Summary
    The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
    Expression
    Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDT1 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88803789..88809258)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94874309..94879778)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88870197..88875666)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene piezo type mechanosensitive ion channel component 1 (Er blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7872 Neighboring gene HSP90AB1 associated lncRNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88810272-88810958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7873 Neighboring gene uncharacterized LOC339059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88829625-88830384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88830385-88831146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88834041-88834626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88834627-88835210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88835211-88835794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88836379-88836962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88836963-88837546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88842592-88843342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88850859-88851772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88856742-88857272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88869451-88870026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88870745-88871628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88871629-88872511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88873249-88873762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88876670-88877205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88878711-88879395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88879396-88880079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88882597-88883098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88883099-88883598 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:88884193-88885392 Neighboring gene adenine phosphoribosyltransferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7882 Neighboring gene uncharacterized LOC107983950 Neighboring gene trafficking protein particle complex subunit 2L

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Meier-Gorlin syndrome 4
    MedGen: C3151120 OMIM: 613804 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Phosphorylation of Chk1 at position Ser345 is required for HIV-1 Vpr-induced G2/M arrest possibly through signaling of DNA re-replication via Cdt1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of nuclear cell cycle DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to sorbitol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication factor Cdt1
    Names
    Double parked, Drosophila, homolog of

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028266.1 RefSeqGene

      Range
      5012..10481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030928.4NP_112190.2  DNA replication factor Cdt1

      See identical proteins and their annotated locations for NP_112190.2

      Status: REVIEWED

      Source sequence(s)
      AB053172, AC092384, BC000137
      Consensus CDS
      CCDS32510.1
      UniProtKB/Swiss-Prot
      Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0, Q9H211
      Related
      ENSP00000301019.4, ENST00000301019.9
      Conserved Domains (2) summary
      cd08674
      Location:168352
      Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
      cd08767
      Location:415537
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      88803789..88809258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      94874309..94879778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)