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    UBQLN2 ubiquilin 2 [ Homo sapiens (human) ]

    Gene ID: 29978, updated on 5-May-2024

    Summary

    Official Symbol
    UBQLN2provided by HGNC
    Official Full Name
    ubiquilin 2provided by HGNC
    Primary source
    HGNC:HGNC:12509
    See related
    Ensembl:ENSG00000188021 MIM:300264; AllianceGenome:HGNC:12509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157
    Summary
    This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
    Orthologs
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    Genomic context

    See UBQLN2 in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (56563627..56567868)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (55856941..55861182)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (56590060..56594301)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 8 Neighboring gene uncharacterized LOC124900486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:56140677-56141176 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:56589763-56590390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29688 Neighboring gene uncharacterized LOC124905194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20869 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene negative regulator of P-body association

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquilin 2 (UBQLN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10167, FLJ56541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of G protein-coupled receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubiquilin-2
    Names
    Nedd4 binding protein 4
    protein linking IAP with cytoskeleton 2
    ubiquitin-like product Chap1/Dsk2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016249.1 RefSeqGene

      Range
      5001..8418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_665

    mRNA and Protein(s)

    1. NM_013444.4NP_038472.2  ubiquilin-2

      See identical proteins and their annotated locations for NP_038472.2

      Status: REVIEWED

      Source sequence(s)
      AF189009, AL354793, AU310783, BC069237, BI602998
      Consensus CDS
      CCDS14374.1
      UniProtKB/Swiss-Prot
      O94798, Q5D027, Q9H3W6, Q9HAZ4, Q9UHD9
      UniProtKB/TrEMBL
      B4DZF1
      Related
      ENSP00000345195.5, ENST00000338222.7
      Conserved Domains (4) summary
      smart00727
      Location:382426
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:33103
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:33103
      UBQ; Ubiquitin homologues
      cd14399
      Location:581620
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      56563627..56567868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      55856941..55861182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)