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    ZMYND10 zinc finger MYND-type containing 10 [ Homo sapiens (human) ]

    Gene ID: 51364, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZMYND10provided by HGNC
    Official Full Name
    zinc finger MYND-type containing 10provided by HGNC
    Primary source
    HGNC:HGNC:19412
    See related
    Ensembl:ENSG00000004838 MIM:607070; AllianceGenome:HGNC:19412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLU; FLU; CILD22; DNAAF7
    Summary
    This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Restricted expression toward testis (RPKM 91.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZMYND10 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50341112..50345732, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50370836..50375456, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50378543..50383163, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19901 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene Ras association domain family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50374977-50375548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19903 Neighboring gene RASSF1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:50377372-50378195 and GRCh37_chr3:50378196-50379018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50380164-50380746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50382474-50383024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50383025-50383575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19905 Neighboring gene CYB561D2-LOC101928965 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene cytochrome b561 family member D2 Neighboring gene transmembrane protein 115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50396255-50397145

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inner dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriolar satellite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger MYND domain-containing protein 10
    Names
    Ciliary dyskinesia, primary, 22
    dynein axonemal assembly factor 7
    protein BLu
    tumor suppressor BLU

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042828.1 RefSeqGene

      Range
      5015..9635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308379.2NP_001295308.1  zinc finger MYND domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001295308.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BE500984, DB036846, U70880
      Consensus CDS
      CCDS77747.1
      UniProtKB/Swiss-Prot
      O75800
      Related
      ENSP00000353289.3, ENST00000360165.7
      Conserved Domains (1) summary
      pfam01753
      Location:389425
      zf-MYND; MYND finger
    2. NM_015896.4NP_056980.2  zinc finger MYND domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_056980.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK315123, BC022186, DB036846
      Consensus CDS
      CCDS2825.1
      UniProtKB/Swiss-Prot
      A6NK41, B3KU54, O14570, O75800, O75801, Q53FE6, Q8N4R6, Q8NDN6
      Related
      ENSP00000231749.3, ENST00000231749.8
      Conserved Domains (1) summary
      pfam01753
      Location:394430
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      50341112..50345732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265216.4XP_005265273.1  zinc finger MYND domain-containing protein 10 isoform X1

      Conserved Domains (1) summary
      pfam01753
      Location:315351
      zf-MYND; MYND finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      50370836..50375456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346774.1XP_054202749.1  zinc finger MYND domain-containing protein 10 isoform X1