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    KATNB1 katanin regulatory subunit B1 [ Homo sapiens (human) ]

    Gene ID: 10300, updated on 5-Mar-2024

    Summary

    Official Symbol
    KATNB1provided by HGNC
    Official Full Name
    katanin regulatory subunit B1provided by HGNC
    Primary source
    HGNC:HGNC:6217
    See related
    Ensembl:ENSG00000140854 MIM:602703; AllianceGenome:HGNC:6217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT; LIS6
    Summary
    Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 14.6), brain (RPKM 7.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See KATNB1 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57735770..57757244)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63530976..63552401)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57769682..57791156)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57710685-57711625 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10909 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57777601-57778101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57790901-57791540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57808554-57809132 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57809711-57810289 Neighboring gene kinesin family member C3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57817648-57818250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57818251-57818852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57819145-57819804 Neighboring gene microRNA 6772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57820464-57821122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57821123-57821781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57828526-57829344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57829345-57830161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57835346-57836022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57836700-57837376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57850615-57851160 Neighboring gene uncharacterized LOC388282

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    part_of katanin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of katanin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of katanin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of katanin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of katanin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    katanin p80 WD40 repeat-containing subunit B1
    Names
    katanin (80 kDa)
    katanin p80 (WD repeat containing) subunit B 1
    katanin p80 (WD40-containing) subunit B 1
    katanin p80 WD40-containing subunit B1
    katanin p80 subunit B1
    p80 katanin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046947.1 RefSeqGene

      Range
      5051..26525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005886.3NP_005877.2  katanin p80 WD40 repeat-containing subunit B1

      See identical proteins and their annotated locations for NP_005877.2

      Status: REVIEWED

      Source sequence(s)
      AF052432, BC001353, BU501165
      Consensus CDS
      CCDS10788.1
      UniProtKB/Swiss-Prot
      A6NCG6, O60620, Q9BVA0
      Related
      ENSP00000368982.3, ENST00000379661.8
      Conserved Domains (4) summary
      cd00200
      Location:7257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67103
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:497648
      Katanin_con80; con80 domain of Katanin
      cl26386
      Location:386494
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57735770..57757244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63530976..63552401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)