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    TEK TEK receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 7010, updated on 2-May-2024

    Summary

    Official Symbol
    TEKprovided by HGNC
    Official Full Name
    TEK receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:11724
    See related
    Ensembl:ENSG00000120156 MIM:600221; AllianceGenome:HGNC:11724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B
    Summary
    This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in lung (RPKM 19.9), placenta (RPKM 18.9) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    9p21.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (27109141..27230178)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (27119713..27240739)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27109139..27230176)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene Sharpr-MPRA regulatory region 6395 Neighboring gene MPRA-validated peak7214 silencer Neighboring gene uncharacterized LOC124902134 Neighboring gene RNA, 5S ribosomal pseudogene 280 Neighboring gene ribosomal protein L36a pseudogene 34 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:27239318-27239818 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:27239819-27240319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251147-27251648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251649-27252148 Neighboring gene long intergenic non-protein coding RNA 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27279903-27280404 Neighboring gene equatorin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Tie signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in definitive hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endochondral ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glomerulus vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart trabecula formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of endothelial cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endothelial cell apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    angiopoietin-1 receptor
    Names
    TEK tyrosine kinase, endothelial
    endothelial tyrosine kinase
    tunica interna endothelial cell kinase
    tyrosine kinase with Ig and EGF homology domains-2
    tyrosine-protein kinase receptor TEK
    tyrosine-protein kinase receptor TIE-2
    NP_000450.3
    NP_001362404.1
    NP_001362405.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011828.2 RefSeqGene

      Range
      5086..126035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000459.5NP_000450.3  angiopoietin-1 receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL133411, AL355432, AL355433
      Consensus CDS
      CCDS6519.1
      UniProtKB/Swiss-Prot
      A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q02763, Q5TCU2, Q8IV34
      UniProtKB/TrEMBL
      Q59HG2
      Related
      ENSP00000369375.4, ENST00000380036.10
      Conserved Domains (6) summary
      cd05088
      Location:8161118
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00055
      Location:230275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:639731
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:544626
      fn3; Fibronectin type III domain
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
      cd20964
      Location:348439
      IgI_Tie2; Immunoglobulin domain of Tie2 tyrosine kinase; a member of the I-set of IgSF domains
    2. NM_001290077.2NP_001277006.2  angiopoietin-1 receptor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL133411, AL355432, AL355433
      Consensus CDS
      CCDS75825.1
      Related
      ENSP00000383977.4, ENST00000406359.8
    3. NM_001290078.2NP_001277007.2  angiopoietin-1 receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL133411, AL355432, AL355433
      Consensus CDS
      CCDS78389.1
      Related
      ENSP00000430686.1, ENST00000519097.5
    4. NM_001375475.1NP_001362404.1  angiopoietin-1 receptor isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL133411, AL355432, AL355433
      UniProtKB/TrEMBL
      Q59HG2
      Conserved Domains (4) summary
      cd05088
      Location:8151117
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00055
      Location:230275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
      pfam00041
      Location:640723
      fn3; Fibronectin type III domain
    5. NM_001375476.1NP_001362405.1  angiopoietin-1 receptor isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL133411, AL355432, AL355433
      UniProtKB/TrEMBL
      Q59HG2
      Conserved Domains (4) summary
      cd05088
      Location:7721074
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00055
      Location:230275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
      pfam00041
      Location:597680
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      27109141..27230178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      27119713..27240739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)