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    Entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85260, updated on 24-Apr-2024

    Summary

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    Official Symbol
    Entpd6provided by RGD
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 6provided by RGD
    Primary source
    RGD:619725
    See related
    Ensembl:ENSRNOG00000007427 AllianceGenome:RGD:619725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables pyrophosphatase activity. Involved in response to calcium ion and response to magnesium ion. Located in several cellular components, including Golgi apparatus; cell surface; and extracellular space. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 106.9), Heart (RPKM 63.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Entpd6 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160036055..160058580)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139575659..139598163)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146546424..146568828)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350499 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486465 Neighboring gene glycogen phosphorylase B Neighboring gene abhydrolase domain containing 12, lysophospholipase Neighboring gene uncharacterized LOC134486181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction. O'Keeffe MG, et al. J Vestib Res, 2012. PMID 23302703
    2. Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function. Ivanenkov VV, et al. Biochemistry, 2003 Oct 14. PMID 14529283
    3. Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family. Braun N, et al. Biochem J, 2000 Nov 1. PMID 11042118, Free PMC Article
    4. Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2). Hicks-Berger CA, et al. J Biol Chem, 2000 Nov 3. PMID 10948193
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTPDase6 immunolocalisation in the vestibular end organ could be linked to the regulation of P2 receptor signalling and sensory transduction, including maintenance of vestibular hair bundles.
      Title: Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 6
    Names
    CD39 antigen-like 2
    NTPDase 6
    NP_445950.1
    XP_006235280.1
    XP_063140810.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429515.1 → NP_001416444.1  ectonucleoside triphosphate diphosphohydrolase 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_053498.1 → NP_445950.1  ectonucleoside triphosphate diphosphohydrolase 6

      See identical proteins and their annotated locations for NP_445950.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ277748
      UniProtKB/Swiss-Prot
      Q9ER31
      UniProtKB/TrEMBL
      A6KHG0
      Related
      ENSRNOP00000009946.3, ENSRNOT00000009946.6
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160036055..160058580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284740.1 → XP_063140810.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    2. XM_006235218.5 → XP_006235280.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9ER31
      UniProtKB/TrEMBL
      A6KHG0
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_010064708.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER31.1 GenPept UniProtKB/Swiss-Prot:Q9ER31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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