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    CG2059 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31663, updated on 10-May-2024

    Summary

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    Official Symbol
    CG2059provided by FlyBase
    Primary source
    FLYBASE:FBgn0029942
    Locus tag
    Dmel_CG2059
    See related
    AllianceGenome:FB:FBgn0029942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2059
    Summary
    Enables carboxylic ester hydrolase activity and serine hydrolase activity. Predicted to be active in mitochondrion. Orthologous to human ABHD11 (abhydrolase domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG2059 in Genome Data Viewer
    Location:
    7B1-7B1; 1-20 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7286358..7288117)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7180391..7182150)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32730 Neighboring gene long non-coding RNA:CR44357 Neighboring gene Chronophage Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unc-119 Neighboring gene brinker

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of gene conversion associated with a selective sweep in Drosophila melanogaster. Glinka S, et al. Mol Biol Evol, 2006 Oct. PMID 16868022
    2. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
    3. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
    4. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article
    5. A journey into the world of insect lipid metabolism. Toprak U, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32335968

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2059-PA
    CG2059-PB
    NP_001188553.1
    NP_572388.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7286358..7288117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201624.1 → NP_001188553.1  uncharacterized protein Dmel_CG2059, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E5L2, Q0E5M5, Q0E5N0, Q9W3R8
      Conserved Domains (3) summary
      PRK10673
      Location:38 → 305
      PRK10673; acyl-CoA esterase; Provisional
      pfam12695
      Location:54 → 151
      Abhydrolase_5; Alpha/beta hydrolase family
      cl21494
      Location:253 → 287
      Abhydrolase; alpha/beta hydrolases

    2. NM_132160.3 → NP_572388.1  uncharacterized protein Dmel_CG2059, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E5L2, Q0E5M5, Q0E5N0, Q9W3R8
      Related
      FBpp0071006
      Conserved Domains (3) summary
      PRK10673
      Location:38 → 305
      PRK10673; acyl-CoA esterase; Provisional
      pfam12695
      Location:54 → 151
      Abhydrolase_5; Alpha/beta hydrolase family
      cl21494
      Location:253 → 287
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3R8 Q9W3R8

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