Pglyrp1 peptidoglycan recognition protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pglyrp1provided by MGI
Official Full Name: peptidoglycan recognition protein 1provided by MGI
Primary source: MGI:MGI:1345092
See related: Ensembl:ENSMUSG00000030413 AllianceGenome:MGI:1345092
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGRP; Tag7; Tasg7; PGRP-S; Pglyrp; Tnfsf3l
Summary: Predicted to enable peptidoglycan binding activity and peptidoglycan immune receptor activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; negative regulation of interferon-gamma production; and negative regulation of natural killer cell differentiation involved in immune response. Predicted to be located in cytoplasm and extracellular space. Is expressed in alimentary system; craniocervical region bone; genitourinary system; liver; and respiratory system. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 543.4), duodenum adult (RPKM 351.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 9.38 cM; 7 A3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18618615..18624363)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (18884690..18890438)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
Title: The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation.
Title: Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation.
Short Peptides of Innate Immunity Protein Tag7 Inhibit the Production of Cytokines in CFA-Induced Arthritis.
Title: Short Peptides of Innate Immunity Protein Tag7 Inhibit the Production of Cytokines in CFA-Induced Arthritis.
A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
Title: A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
our results show that Pglyrp1 enhances allergic asthmatic responses primarily through its effect on the host intestinal microbiome and identify several bacteria that may increase or decrease sensitivity to asthma.
Title: The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma.
Tag7 activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
Title: Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7-Hsp70 and the Tag 7 component of this complex with TNFR1 receptor in solution and in tumor cells are presented.
Title: Apoptotic tumor cell death under the influence of the cytotoxic complex Tag7-Hsp70 is induced by interaction with the TNFR1 receptor.
Both compounds down regulated mucin 5 subtype B, and peptidoglycan recognition protein 1 in vaginal tissue
Title: New candidate biomarkers in the female genital tract to evaluate microbicide toxicity.
Pglyrp1 expressed by hematopoietic cells, such as alveolar macrophages, mediates house dust mite-induced airway inflammation by up-regulating the production of C-C chemokines that recruit eosinophils and Th2 cells to the lung.
Title: Peptidoglycan recognition protein 1 promotes house dust mite-induced airway inflammation in mice.
Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.
Title: Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D7Mit191.2 (e-PCR), detects polymorphism
- UniSTS:131083

NoName (e-PCR)
- UniSTS:224548

D7Dcr1 (e-PCR), detects polymorphism
- UniSTS:507765

MT2216 (e-PCR)
- UniSTS:116703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biological process involved in interaction with host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidoglycan recognition protein 1

Names: cytokine tag7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009402.2 → NP_033428.1 peptidoglycan recognition protein 1 precursor

See identical proteins and their annotated locations for NP_033428.1

Status: PROVISIONAL

Source sequence(s)

AC153651

Consensus CDS

CCDS20881.1

UniProtKB/Swiss-Prot

O88593, Q62185

UniProtKB/TrEMBL

Q4FK86

Related

ENSMUSP00000032573.7, ENSMUST00000032573.8

Conserved Domains (1) summary

smart00701
Location:20 → 160

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme