Ren2 renin 2 tandem duplication of Ren1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ren2provided by MGI
Official Full Name: renin 2 tandem duplication of Ren1provided by MGI
Primary source: MGI:MGI:97899
See related: AllianceGenome:MGI:97899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ren; Rnr; Rn-2; Ren-2; Ren-B
Summary: Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Genomic context

Location:: 1 E4; 1

Annotation release	Status	Assembly	Chr	Location
108.20200622	latest, but not current	GRCm38.p6 (GCF_000001635.26)	1 Unlocalized Scaffold (129S6/SvEvTac)	NT_039192.2 (159748..169505, complement)

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
Title: Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
Sex differences in blood pressure of aged Ren-2 transgenic rats.
Title: Sex differences in blood pressure of aged Ren-2 transgenic rats.
Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
Title: Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat.
Title: Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats.
Title: Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
Title: Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
A deficitcin Ang-(1-7) in the brain of hypertensive (mRen2)27 rats maycbe a contributing factor to higher blood pressure and alteredcautonomic balance in this strain.
Title: In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats.
Data show that the GPR30 agonist G-1 mitigates the adverse effects of oestrogen loss on LV remodelling and the development of diastolic dysfunction in oophorectomized mRen2 Lew rats.
Title: Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats.
Renin and PPAR-gamma differentially contribute to the control of the length of cardiomyocytes.
Title: Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}.
Epoxide hydrolase inhibitors displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function.
Title: Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Ren1 (e-PCR), detects polymorphism
- UniSTS:464689

D19352 (e-PCR)
- UniSTS:158852

Ren1 (e-PCR), detects polymorphism
- UniSTS:545979

X16642 (e-PCR)
- UniSTS:163263

Ren2 (e-PCR), detects polymorphism
- UniSTS:507386

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiotensin maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: renin-2

Names: angiotensinogenase; submandibular gland renin

NP_112470.2

EC 3.4.23.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031193.2 → NP_112470.2 renin-2 precursor

Status: VALIDATED

Source sequence(s)

BC011157, BG867251, BG869802

UniProtKB/Swiss-Prot

P00796, P70229, P97955, Q62155

Conserved Domains (3) summary

cd05487
Location:98 → 423

renin_like; Renin stimulates production of angiotensin and thus affects blood pressure

pfam00026
Location:105 → 423

Asp; Eukaryotic aspartyl protease

pfam07966
Location:51 → 76

A1_Propeptide; A1 Propeptide