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    Fkbp15 FK506 binding protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 338355, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fkbp15provided by MGI
    Official Full Name
    FK506 binding protein 15provided by MGI
    Primary source
    MGI:MGI:2444782
    See related
    Ensembl:ENSMUSG00000066151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKBP13; FKBO133; FKBP-15; FKBP133; BB131447; FKBP-133; mKIAA0674; C430014M02Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 9.8), lung adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fkbp15 in Genome Data Viewer
    Location:
    4; 4 B3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62218579..62278833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62300342..62360596, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (61961376..62021582, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23148 Neighboring gene solute carrier family 31, member 2 Neighboring gene solute carrier family 31, member 1 Neighboring gene cell division cycle 26 Neighboring gene pre-mRNA processing factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0674, MGC169330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FK506-binding protein 15
    Names
    133 kDa FK506-binding protein
    133 kDa FKBP
    FK506-binding protein 133
    WAFL
    NP_001038993.1
    NP_001342314.1
    XP_006538097.1
    XP_030109487.1
    XP_036020098.1
    XP_036020099.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045528.2NP_001038993.1  FK506-binding protein 15 isoform 1

      See identical proteins and their annotated locations for NP_001038993.1

      Status: VALIDATED

      Source sequence(s)
      AK049509, BC060651, CJ044507
      Consensus CDS
      CCDS51201.1
      UniProtKB/Swiss-Prot
      Q6P9Q6
      Related
      ENSMUSP00000081575.4, ENSMUST00000084527.10
      Conserved Domains (4) summary
      pfam00254
      Location:192285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam07321
      Location:677806
      YscO; Type III secretion protein YscO
      cl23720
      Location:679774
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23765
      Location:596750
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_001355385.1NP_001342314.1  FK506-binding protein 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK049509, AK082565, BC060651, CJ044507
      Conserved Domains (4) summary
      pfam00254
      Location:192285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      cl25732
      Location:556915
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26464
      Location:9341119
      Atrophin-1; Atrophin-1 family
      cl28087
      Location:378489
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62218579..62278833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164206.1XP_036020099.1  FK506-binding protein 15 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:505690
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:122430
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_030253627.1XP_030109487.1  FK506-binding protein 15 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:495680
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:117456
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_006538034.4XP_006538097.1  FK506-binding protein 15 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Q6
      Related
      ENSMUSP00000159322.2, ENSMUST00000239461.2
      Conserved Domains (4) summary
      PHA03247
      Location:9441129
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:561890
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:378489
      PRK10263; DNA translocase FtsK; Provisional
      pfam00254
      Location:192285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    4. XM_036164205.1XP_036020098.1  FK506-binding protein 15 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:792977
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:409738
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00254
      Location:40133
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
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