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    Proz protein Z, vitamin K-dependent plasma glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 66901, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prozprovided by MGI
    Official Full Name
    protein Z, vitamin K-dependent plasma glycoproteinprovided by MGI
    Primary source
    MGI:MGI:1860488
    See related
    Ensembl:ENSMUSG00000031445 AllianceGenome:MGI:1860488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300015B06Rik
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within blood coagulation. Located in extracellular region. Is expressed in liver and plasma. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 113.6), liver E18 (RPKM 53.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13110583..13126026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13060584..13076026)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor VII Neighboring gene coagulation factor X Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice. Butschkau A, et al. Int J Clin Exp Pathol, 2014. PMID 25337252, Free PMC Article
    2. Protein z exerts pro-angiogenic effects and upregulates CXCR4. Butschkau A, et al. PLoS One, 2014. PMID 25474349, Free PMC Article
    3. Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. Butschkau A, et al. Crit Care Med, 2013 Dec. PMID 23963134, Free PMC Article
    4. Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. Girard TJ, et al. J Thromb Haemost, 2013 Feb. PMID 23205927, Free PMC Article
    5. Mouse protein Z-dependent protease inhibitor cDNA. Zhang J, et al. Thromb Haemost, 2001 May. PMID 11372680

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PZ contributes to a reduced neointima formation after vascular injury, underlining the modulatory role of the coagulation cascade in vascular homeostasis.
      Title: Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice.
    2. Letter: protein Z is not a typical acute phase reactant.
      Title: Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
    3. PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
      Title: Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood coagulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vitamin K-dependent protein Z

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357219.1 → NP_001344148.1  vitamin K-dependent protein Z isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC127308
      Consensus CDS
      CCDS90373.1
      UniProtKB/TrEMBL
      Q8CI01
      Related
      ENSMUSP00000147733.2, ENSMUST00000211363.2
      Conserved Domains (4) summary
      smart00069
      Location:23 → 85
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136 → 165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl27237
      Location:192 → 239
      Trypsin; Trypsin

    2. NM_001357220.1 → NP_001344149.1  vitamin K-dependent protein Z isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127308
      UniProtKB/TrEMBL
      Q05CL2
      Conserved Domains (3) summary
      cd00054
      Location:25 → 52
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00089
      Location:122 → 270
      Trypsin; Trypsin
      pfam14670
      Location:66 → 95
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. NM_025834.4 → NP_080110.1  vitamin K-dependent protein Z isoform 1 precursor

      See identical proteins and their annotated locations for NP_080110.1

      Status: VALIDATED

      Source sequence(s)
      AC127308, AK005011, AK008819
      Consensus CDS
      CCDS22105.1
      UniProtKB/Swiss-Prot
      Q9CQW3
      Related
      ENSMUSP00000033822.3, ENSMUST00000033822.4
      Conserved Domains (5) summary
      smart00069
      Location:23 → 85
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00089
      Location:192 → 340
      Trypsin; Trypsin
      pfam14670
      Location:136 → 165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl21584
      Location:192 → 397
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13110583..13126026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508859.5 → XP_006508922.1  vitamin K-dependent protein Z isoform X2

      Conserved Domains (3) summary
      smart00069
      Location:23 → 85
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136 → 165
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_006508858.4 → XP_006508921.1  vitamin K-dependent protein Z isoform X1

      Conserved Domains (3) summary
      smart00069
      Location:23 → 85
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136 → 165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQW3.1 GenPept UniProtKB/Swiss-Prot:Q9CQW3

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