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    Urah urate (5-hydroxyiso-) hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 76974, updated on 22-Aug-2021

    Summary

    Official Symbol
    Urahprovided by MGI
    Official Full Name
    urate (5-hydroxyiso-) hydrolaseprovided by MGI
    Primary source
    MGI:MGI:1916142
    See related
    Ensembl:ENSMUSG00000025481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIUHase; 1190003J15Rik; 2810420C16Rik
    Expression
    Biased expression in liver adult (RPKM 258.8), liver E18 (RPKM 41.1) and 2 other tissues See more
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    Genomic context

    See Urah in Genome Data Viewer
    Location:
    7; 7 F4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140414936..140417884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140834958..140837971)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148021395..148023867)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 1 Neighboring gene predicted gene, 29799 Neighboring gene zinc finger protein 941 Neighboring gene RIKEN cDNA C330022C24 gene Neighboring gene secretoglobin, family 1C, member 1 Neighboring gene outer dense fiber of sperm tails 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1)  1 citation

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydroxyisourate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    PubMed 

    General protein information

    Preferred Names
    5-hydroxyisourate hydrolase
    Names
    HIU hydrolase
    transthyretin-related protein
    NP_001334534.1
    NP_001346734.1
    NP_084097.1
    XP_030098952.1
    XP_030098953.1
    XP_036009449.1
    XP_036009450.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347605.1NP_001334534.1  5-hydroxyisourate hydrolase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC107815
      Consensus CDS
      CCDS85453.1
      UniProtKB/TrEMBL
      A0A0A0MQC3
      Related
      ENSMUSP00000101665.3, ENSMUST00000106050.8
    2. NM_001359805.1NP_001346734.1  5-hydroxyisourate hydrolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA510160, AC107815, AK004470, BP776625
      Consensus CDS
      CCDS21986.1
      Related
      ENSMUSP00000147522.2, ENSMUST00000211372.2
      Conserved Domains (1) summary
      cd05822
      Location:6118
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...
    3. NM_029821.3NP_084097.1  5-hydroxyisourate hydrolase isoform 2

      See identical proteins and their annotated locations for NP_084097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK004470, AK013117, BP776625, BY145477
      Consensus CDS
      CCDS21986.1
      UniProtKB/Swiss-Prot
      Q9CRB3
      Related
      ENSMUSP00000026554.5, ENSMUST00000026554.11
      Conserved Domains (1) summary
      cd05822
      Location:6118
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140414936..140417884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243092.2XP_030098952.1  5-hydroxyisourate hydrolase isoform X1

      Conserved Domains (1) summary
      cl21470
      Location:29112
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    2. XM_036153557.1XP_036009450.1  5-hydroxyisourate hydrolase isoform X2

      Related
      ENSMUSP00000147888.2, ENSMUST00000209978.2
      Conserved Domains (1) summary
      cl21470
      Location:689
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    3. XM_030243093.1XP_030098953.1  5-hydroxyisourate hydrolase isoform X3

      Related
      ENSMUSP00000147435.2, ENSMUST00000210916.2
      Conserved Domains (1) summary
      cd05822
      Location:6118
      TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...
    4. XM_036153556.1XP_036009449.1  5-hydroxyisourate hydrolase isoform X2

      Conserved Domains (1) summary
      cl21470
      Location:689
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
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