Sec11c SEC11 homolog C, signal peptidase complex subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec11cprovided by MGI
Official Full Name: SEC11 homolog C, signal peptidase complex subunitprovided by MGI
Primary source: MGI:MGI:1913536
See related: Ensembl:ENSMUSG00000024516 AllianceGenome:MGI:1913536
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sec11l3; 1810029G24Rik
Summary: Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; respiratory system; sensory organ; and telencephalon. Orthologous to human SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 32.7), cerebellum adult (RPKM 26.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 38.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (65933649..65950731)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (65800578..65817660)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal peptidase complex catalytic subunit SEC11C

Names: SEC11-like protein 3; SPC21; SPase 21 kDa subunit; Sec11-like 3; microsomal signal peptidase 21 kDa subunit

NP_079744.1

EC 3.4.21.89

XP_006526213.1

EC 3.4.21.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025468.2 → NP_079744.1 signal peptidase complex catalytic subunit SEC11C

See identical proteins and their annotated locations for NP_079744.1

Status: PROVISIONAL

Source sequence(s)

AK007641

Consensus CDS

CCDS29309.1

UniProtKB/Swiss-Prot

Q9D8V7

UniProtKB/TrEMBL

D3Z5H3

Related

ENSMUSP00000025394.7, ENSMUST00000025394.14

Conserved Domains (1) summary

cl10465
Location:34 → 167

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

65933649..65950731

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526150.3 → XP_006526213.1 signal peptidase complex catalytic subunit SEC11C isoform X1

See identical proteins and their annotated locations for XP_006526213.1

Conserved Domains (1) summary

cl10465
Location:12 → 129

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...