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    Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [ Mus musculus (house mouse) ]

    Gene ID: 16149, updated on 2-Oct-2021

    Summary

    Official Symbol
    Cd74provided by MGI
    Official Full Name
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)provided by MGI
    Primary source
    MGI:MGI:96534
    See related
    Ensembl:ENSMUSG00000024610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
    Expression
    Biased expression in spleen adult (RPKM 2800.7), large intestine adult (RPKM 1812.1) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd74 in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60936921..60945724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60803849..60812652)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (60963503..60972306)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 Neighboring gene 40S ribosomal protein S16 pseudogene Neighboring gene microRNA 5107 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene predicted gene, 41744

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MHC class II protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MHC class II protein binding, via antigen binding groove ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables macrophage migration inhibitory factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage migration inhibitory factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mature B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage migration inhibitory factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein trimerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NOS2-CD74 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of macrophage migration inhibitory factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of macrophage migration inhibitory factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    H-2 class II histocompatibility antigen gamma chain
    Names
    HLA-DR-GAMMA
    Ia-associated invariant chain
    MHC class II-associated invariant chain
    class II-associated invariant chain peptide
    dinucleotide microsatellite
    histocompatibility: class II antigens, gamma chain of
    ia antigen-associated invariant chain
    ii chain
    invariant polypeptide of major histocompatibility complex, class II antigen-associated

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042605.1NP_001036070.1  H-2 class II histocompatibility antigen gamma chain isoform 1

      See identical proteins and their annotated locations for NP_001036070.1

      Status: VALIDATED

      Source sequence(s)
      AK002232, AW123644, BG148172
      Consensus CDS
      CCDS37835.1
      UniProtKB/Swiss-Prot
      P04441
      UniProtKB/TrEMBL
      Q3U4Q8, Q545Y5
      Related
      ENSMUSP00000095171.3, ENSMUST00000097563.9
      Conserved Domains (3) summary
      cd00191
      Location:195254
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam08831
      Location:119184
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:1111
      MHC2-interact; CLIP, MHC2 interacting
    2. NM_010545.3NP_034675.1  H-2 class II histocompatibility antigen gamma chain isoform 2

      See identical proteins and their annotated locations for NP_034675.1

      Status: VALIDATED

      Source sequence(s)
      AK002232, AW123644
      Consensus CDS
      CCDS50299.1
      UniProtKB/TrEMBL
      Q545Y5
      Related
      ENSMUSP00000057836.9, ENSMUST00000050487.16
      Conserved Domains (2) summary
      pfam08831
      Location:119184
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:1111
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60936921..60945724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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