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    POLR3H RNA polymerase III subunit H [ Homo sapiens (human) ]

    Gene ID: 171568, updated on 8-Jul-2021

    Summary

    Official Symbol
    POLR3Hprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Hprovided by HGNC
    Primary source
    HGNC:HGNC:30349
    See related
    Ensembl:ENSG00000100413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C25; RPC8; RPC22.9
    Expression
    Ubiquitous expression in heart (RPKM 36.2), kidney (RPKM 22.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POLR3H in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41525799..41544606, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41921803..41940610, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2 Neighboring gene Sharpr-MPRA regulatory region 731 Neighboring gene uncharacterized LOC105373044 Neighboring gene cold shock domain containing C2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1665, MGC29654, MGC111097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC8
    Names
    DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide
    DNA-directed RNA polymerase III subunit H
    RNA nucleotidyltransferase (DNA-directed)
    RNA polymerase III subunit C8
    polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
    polymerase (RNA) III subunit H
    NP_001018060.1
    NP_001018062.1
    NP_001269813.1
    NP_001269814.1
    NP_612211.1
    XP_011528295.1
    XP_016884130.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018050.4NP_001018060.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      See identical proteins and their annotated locations for NP_001018060.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
      Source sequence(s)
      AB051452, AK000365, AL023553, BM701572, DA238361, DA449644
      Consensus CDS
      CCDS14018.1
      UniProtKB/Swiss-Prot
      Q9Y535
      UniProtKB/TrEMBL
      A0A024R1P3
      Related
      ENSP00000347345.4, ENST00000355209.9
      Conserved Domains (2) summary
      cd04330
      Location:281
      RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
      pfam08292
      Location:83201
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    2. NM_001018052.4NP_001018062.1  DNA-directed RNA polymerase III subunit RPC8 isoform b

      See identical proteins and their annotated locations for NP_001018062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AB051452, AK000365, AL023553, BC017248, BM701572, DA238361, DA449644
      Consensus CDS
      CCDS33651.1
      UniProtKB/Swiss-Prot
      Q9Y535
      Related
      ENSP00000337627.5, ENST00000337566.9
      Conserved Domains (2) summary
      cd04330
      Location:270
      RNAP_III_Rpc25_N; RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, ...
      pfam08292
      Location:69172
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    3. NM_001282884.2NP_001269813.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      See identical proteins and their annotated locations for NP_001269813.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
      Source sequence(s)
      AB051452, AK000365, AL023553, BM701572, BU584298
      Consensus CDS
      CCDS14018.1
      UniProtKB/Swiss-Prot
      Q9Y535
      UniProtKB/TrEMBL
      A0A024R1P3
      Related
      ENSP00000385315.1, ENST00000407461.5
      Conserved Domains (2) summary
      cd04330
      Location:281
      RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
      pfam08292
      Location:83201
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    4. NM_001282885.2NP_001269814.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      See identical proteins and their annotated locations for NP_001269814.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, and 6 encode the same isoform (a).
      Source sequence(s)
      AB051452, AK000365, AL023553, BM701572, BU173504, DA449644
      Consensus CDS
      CCDS14018.1
      UniProtKB/Swiss-Prot
      Q9Y535
      UniProtKB/TrEMBL
      A0A024R1P3
      Conserved Domains (2) summary
      cd04330
      Location:281
      RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
      pfam08292
      Location:83201
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    5. NM_138338.5NP_612211.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      See identical proteins and their annotated locations for NP_612211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 3, 5, and 6 encode the same isoform (a).
      Source sequence(s)
      AB051452, AK000365, AL023553, BM701572, DA504810
      Consensus CDS
      CCDS14018.1
      UniProtKB/Swiss-Prot
      Q9Y535
      UniProtKB/TrEMBL
      A0A024R1P3
      Related
      ENSP00000379761.2, ENST00000396504.6
      Conserved Domains (2) summary
      cd04330
      Location:281
      RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...
      pfam08292
      Location:83201
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      41525799..41544606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529993.1XP_011528295.1  DNA-directed RNA polymerase III subunit RPC8 isoform X1

      Conserved Domains (1) summary
      pfam08292
      Location:33138
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    2. XM_017028641.1XP_016884130.1  DNA-directed RNA polymerase III subunit RPC8 isoform X1

      Conserved Domains (1) summary
      pfam08292
      Location:33138
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

    RNA

    1. XR_244356.3 RNA Sequence

      Related
      ENST00000431534.5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001018051.1: Suppressed sequence

      Description
      NM_001018051.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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