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    MS4A8 membrane spanning 4-domains A8 [ Homo sapiens (human) ]

    Gene ID: 83661, updated on 25-Jan-2022

    Summary

    Official Symbol
    MS4A8provided by HGNC
    Official Full Name
    membrane spanning 4-domains A8provided by HGNC
    Primary source
    HGNC:HGNC:13380
    See related
    Ensembl:ENSG00000166959 MIM:606549; AllianceGenome:HGNC:13380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MS4A4; 4SPAN4; CD20L5; MS4A8B
    Summary
    This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 85.3), duodenum (RPKM 75.4) and 4 other tissues See more
    Orthologs
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    Genomic context

    See MS4A8 in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60699612..60715807)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60467085..60483280)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A19, pseudogene Neighboring gene uncharacterized LOC105369321 Neighboring gene long intergenic non-protein coding RNA 301 Neighboring gene membrane spanning 4-domains A18 Neighboring gene membrane spanning 4-domains A15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    membrane-spanning 4-domains subfamily A member 8
    Names
    four-span transmembrane protein 4
    membrane-spanning 4-domains, subfamily A, member 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031457.2NP_113645.1  membrane-spanning 4-domains subfamily A member 8

      See identical proteins and their annotated locations for NP_113645.1

      Status: REVIEWED

      Source sequence(s)
      AF237905
      Consensus CDS
      CCDS7990.1
      UniProtKB/Swiss-Prot
      Q9BY19
      Related
      ENSP00000300226.2, ENST00000300226.7
      Conserved Domains (1) summary
      pfam04103
      Location:71207
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      60699612..60715807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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