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    Bhmt2 betaine-homocysteine methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 64918, updated on 16-Oct-2021

    Summary

    Official Symbol
    Bhmt2provided by MGI
    Official Full Name
    betaine-homocysteine methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1891379
    See related
    Ensembl:ENSMUSG00000042118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C81077; D13Ucla2
    Expression
    Biased expression in liver adult (RPKM 63.9), liver E18 (RPKM 58.7) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Bhmt2 in Genome Data Viewer
    Location:
    13 C3; 13 47.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93792605..93810810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93656097..93674302, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (94426052..94444257, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31977 Neighboring gene betaine-homocysteine methyltransferase Neighboring gene dimethylglycine dehydrogenase precursor Neighboring gene expressed sequence AW495222 Neighboring gene predicted gene, 41021

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables S-methylmethionine-homocysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables S-methylmethionine-homocysteine S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables betaine-homocysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-methionine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-methylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within methionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    S-methylmethionine--homocysteine S-methyltransferase BHMT2
    Names
    SMM-hcy methyltransferase
    betaine--homocysteine S-methyltransferase 2
    NP_075022.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022884.2NP_075022.2  S-methylmethionine--homocysteine S-methyltransferase BHMT2

      See identical proteins and their annotated locations for NP_075022.2

      Status: VALIDATED

      Source sequence(s)
      AA014354, AK145901
      Consensus CDS
      CCDS26689.1
      UniProtKB/Swiss-Prot
      Q91WS4
      Related
      ENSMUSP00000015941.8, ENSMUST00000015941.8
      Conserved Domains (1) summary
      pfam02574
      Location:23305
      S-methyl_trans; Homocysteine S-methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      93792605..93810810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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