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    Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 13087, updated on 13-Jul-2021

    Summary

    Official Symbol
    Cyp2a5provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily a, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:88597
    See related
    Ensembl:ENSMUSG00000005547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Co; Coh; CYPIIA5; Cyp15a2
    Expression
    Biased expression in liver adult (RPKM 240.7), kidney adult (RPKM 42.6) and 1 other tissue See more
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    Genomic context

    See Cyp2a5 in Genome Data Viewer
    Location:
    7 A3; 7 15.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26534764..26542689)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26835339..26843264)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27620358..27628283)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51442 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 19 Neighboring gene predicted gene, 51443 Neighboring gene cytochrome P450, family 2, subfamily g, polypeptide 1 Neighboring gene Cyp2a5 5' regulatory region Neighboring gene cytochrome P450 2A8-like Neighboring gene apoptosis inhibitor 5, pseudogene Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables coumarin 7-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in coumarin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exogenous drug catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within heme metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome P450 2A5
    Names
    coumarin 7-hydroxylase
    cytochrome P450, 2a5
    cytochrome P450-15-COH
    cytochrome P450-IIA3.2
    NP_031838.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007812.4NP_031838.2  cytochrome P450 2A5

      See identical proteins and their annotated locations for NP_031838.2

      Status: VALIDATED

      Source sequence(s)
      AK132617, AK149439, BC046605
      Consensus CDS
      CCDS21008.1
      UniProtKB/TrEMBL
      Q80XK1, Q91X75
      Related
      ENSMUSP00000005685.9, ENSMUST00000005685.15
      Conserved Domains (1) summary
      pfam00067
      Location:34491
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26534764..26542689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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