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    PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]

    Gene ID: 5142, updated on 26-Sep-2021

    Summary

    Official Symbol
    PDE4Bprovided by HGNC
    Official Full Name
    phosphodiesterase 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:8781
    See related
    Ensembl:ENSG00000184588 MIM:600127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPDE4; PDEIVB
    Summary
    This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PDE4B in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (65792510..66374579)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66258193..66840262)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leptin receptor Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 854, pseudogene Neighboring gene PDE4B antisense RNA 1 Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene uncharacterized LOC105378776 Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene microRNA 3117

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
    GeneReviews: Not available
    Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
    GeneReviews: Not available
    Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
    GeneReviews: Not available
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    GeneReviews: Not available
    The genetic architecture of economic and political preferences.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
    tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed
    tat HIV-1 Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes by recruiting cyclic nucleoside phosphodiesterase 4, resulting in increased susceptibility to HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126529, DKFZp686F2182

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity TAS
    Traceable Author Statement
    more info
     
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane transporter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epinephrine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neutrophil homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of high voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Names
    dunce-like phosphodiesterase E4
    phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
    NP_001032416.1
    NP_001032417.1
    NP_001032418.1
    NP_001284369.1
    NP_001284370.1
    NP_001284371.1
    NP_002591.2
    XP_005270981.1
    XP_005270982.1
    XP_006710743.1
    XP_016856934.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029038.1 RefSeqGene

      Range
      5001..587070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037339.2NP_001032416.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2

      See identical proteins and their annotated locations for NP_001032416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (2, also known as PDE4B2 or PDE32) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AW519027, BC036108, DC399916, L12686, M97515
      Consensus CDS
      CCDS30743.1
      UniProtKB/Swiss-Prot
      Q07343
      Related
      ENSP00000360084.5, ENST00000371045.9
      Conserved Domains (1) summary
      pfam00233
      Location:233470
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001037340.3NP_001032417.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3

      See identical proteins and their annotated locations for NP_001032417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (3, also known as PDE4B3) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AB209081, BC036108, BC101480, L12686
      Consensus CDS
      CCDS30742.1
      UniProtKB/Swiss-Prot
      Q07343
      UniProtKB/TrEMBL
      Q59GM8
      Related
      ENSP00000392947.2, ENST00000423207.6
      Conserved Domains (1) summary
      pfam00233
      Location:390631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. NM_001037341.2NP_001032418.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_001032418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR, compared to variant a. Both variants a and d encode the same isoform (1, also known as PDE4B1 or Tm72).
      Source sequence(s)
      AW519027, BC046161, BC071607, BC101480, DA103627
      Consensus CDS
      CCDS632.1
      UniProtKB/Swiss-Prot
      Q07343
      UniProtKB/TrEMBL
      X5DNX5
      Related
      ENSP00000332116.4, ENST00000329654.8
      Conserved Domains (1) summary
      pfam00233
      Location:405646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. NM_001297440.2NP_001284369.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) differs in the 5' UTR and lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      BC036108, CR749667, DA103627, L12686, M97515
      UniProtKB/Swiss-Prot
      Q07343
      UniProtKB/TrEMBL
      Q68CX5
      Conserved Domains (1) summary
      pfam00233
      Location:313554
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. NM_001297441.1NP_001284370.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) differs in the 5' UTR and contains multiple differences in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AL357273, AL590783, AW519027, BC036108, BF513098, KJ534917, L12686, M97515
      UniProtKB/Swiss-Prot
      Q07343
      UniProtKB/TrEMBL
      X5DR82
      Conserved Domains (1) summary
      pfam00233
      Location:330571
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. NM_001297442.2NP_001284371.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6

      See identical proteins and their annotated locations for NP_001284371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6, also known as PDE4B5) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AK290206, BC036108, L12686, M97515
      Consensus CDS
      CCDS72802.1
      UniProtKB/Swiss-Prot
      Q07343
      Related
      ENSP00000432592.1, ENST00000480109.2
      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. NM_002600.4NP_002591.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_002591.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes the longest isoform (1, also referred to as PDE4B1 or Tm72). Both variants a and d encode the same isoform.
      Source sequence(s)
      AA206316, AA453531, AL513493, BC046161, CN268011, DA126733, L20966
      Consensus CDS
      CCDS632.1
      UniProtKB/Swiss-Prot
      Q07343
      UniProtKB/TrEMBL
      X5DNX5
      Related
      ENSP00000342637.4, ENST00000341517.9
      Conserved Domains (1) summary
      pfam00233
      Location:405646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      65792510..66374579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001445.1XP_016856934.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    2. XM_005270925.2XP_005270982.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      See identical proteins and their annotated locations for XP_005270982.1

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_006710680.3XP_006710743.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      Conserved Domains (1) summary
      pfam00233
      Location:200437
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_005270924.3XP_005270981.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      See identical proteins and their annotated locations for XP_005270981.1

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
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