Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    RBM19 RNA binding motif protein 19 [ Homo sapiens (human) ]

    Gene ID: 9904, updated on 8-Jul-2021

    Summary

    Official Symbol
    RBM19provided by HGNC
    Official Full Name
    RNA binding motif protein 19provided by HGNC
    Primary source
    HGNC:HGNC:29098
    See related
    Ensembl:ENSG00000122965 MIM:616444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mrd1
    Summary
    This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in testis (RPKM 6.2), spleen (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBM19 in Genome Data Viewer
    Location:
    12q24.13-q24.21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113816740..113966371, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (114254545..114404130, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1234 Neighboring gene dynein light chain LC8-type 1 pseudogene 4 Neighboring gene VISTA enhancer hs1673 Neighboring gene tRNA-Glu (anticodon CTC) 16-1 Neighboring gene uncharacterized LOC105369993 Neighboring gene CRE2 enhancer downstream of TBX5 Neighboring gene uncharacterized LOC105369994

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of RNA binding motif protein 19 (RBM19) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0682, DKFZp586F1023

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    probable RNA-binding protein 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146698.2NP_001140170.1  probable RNA-binding protein 19

      See identical proteins and their annotated locations for NP_001140170.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA594568, AC090669, AK291444, AL117547, BC004289, DB096676
      Consensus CDS
      CCDS9172.1
      UniProtKB/Swiss-Prot
      Q9Y4C8
      Related
      ENSP00000376344.3, ENST00000392561.7
      Conserved Domains (8) summary
      COG0724
      Location:477801
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12318
      Location:730809
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12502
      Location:294365
      RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12564
      Location:277
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12567
      Location:400478
      RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12569
      Location:587658
      RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12571
      Location:832910
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      pfam16651
      Location:82286
      RRM_u2; Unstructured region on RNA-binding-domain protein
    2. NM_001146699.2NP_001140171.1  probable RNA-binding protein 19

      See identical proteins and their annotated locations for NP_001140171.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC009731, AC090669, AI218902, AK291444, DB096676
      Consensus CDS
      CCDS9172.1
      UniProtKB/Swiss-Prot
      Q9Y4C8
      Related
      ENSP00000442053.2, ENST00000545145.6
      Conserved Domains (8) summary
      COG0724
      Location:477801
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12318
      Location:730809
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12502
      Location:294365
      RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12564
      Location:277
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12567
      Location:400478
      RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12569
      Location:587658
      RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12571
      Location:832910
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      pfam16651
      Location:82286
      RRM_u2; Unstructured region on RNA-binding-domain protein
    3. NM_016196.4NP_057280.2  probable RNA-binding protein 19

      See identical proteins and their annotated locations for NP_057280.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC009731, AC090669, AL117547, DB096676
      Consensus CDS
      CCDS9172.1
      UniProtKB/Swiss-Prot
      Q9Y4C8
      Related
      ENSP00000261741.5, ENST00000261741.10
      Conserved Domains (8) summary
      COG0724
      Location:477801
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12318
      Location:730809
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12502
      Location:294365
      RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12564
      Location:277
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12567
      Location:400478
      RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12569
      Location:587658
      RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12571
      Location:832910
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      pfam16651
      Location:82286
      RRM_u2; Unstructured region on RNA-binding-domain protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      113816740..113966371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020280.1XP_016875769.1  probable RNA-binding protein 19 isoform X1

      Conserved Domains (8) summary
      COG0724
      Location:453777
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12318
      Location:706785
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12564
      Location:277
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12567
      Location:376454
      RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12569
      Location:563634
      RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12571
      Location:808886
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      pfam16651
      Location:82286
      RRM_u2; Unstructured region on RNA-binding-domain protein
      cl17169
      Location:294341
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_017020281.1XP_016875770.1  probable RNA-binding protein 19 isoform X1

      Conserved Domains (8) summary
      COG0724
      Location:453777
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12318
      Location:706785
      RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
      cd12564
      Location:277
      RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12567
      Location:376454
      RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12569
      Location:563634
      RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
      cd12571
      Location:808886
      RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
      pfam16651
      Location:82286
      RRM_u2; Unstructured region on RNA-binding-domain protein
      cl17169
      Location:294341
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_001748932.1 RNA Sequence

    2. XR_944848.2 RNA Sequence

    Support Center