Ddx60 DExD/H box helicase 60 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx60provided by MGI
Official Full Name: DExD/H box helicase 60provided by MGI
Primary source: MGI:MGI:2384570
See related: Ensembl:ENSMUSG00000037921 AllianceGenome:MGI:2384570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9830118M07
Summary: Enables RNA binding activity. Acts upstream of or within defense response to virus. Located in cytoplasm. Is expressed in lens. Orthologous to human DDX60 (DExD/H-box helicase 60). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 8 B3.1; 8 31.51 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (62381155..62491278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (61928073..62037704)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning.
Title: Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning.
overexpression of DDX60 did not potentiate IFN induction
Title: Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.
Results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation.
Title: DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
DDX60 is a novel antiviral helicase promoting RIG-I-like receptor-mediated signaling.
Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ddx60 (e-PCR), detects polymorphism
- UniSTS:525632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX60

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

NP_001280712.1

EC 3.6.4.13

XP_006509456.1

EC 3.6.4.13

XP_006509459.1

EC 3.6.4.13

XP_011240516.1

EC 3.6.4.13

XP_017168186.1

EC 3.6.4.13

XP_017168187.1

EC 3.6.4.13

XP_036009806.1

EC 3.6.4.13

XP_036009807.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293783.2 → NP_001280712.1 probable ATP-dependent RNA helicase DDX60

See identical proteins and their annotated locations for NP_001280712.1

Status: VALIDATED

Source sequence(s)

AC139846, AC144858

Consensus CDS

CCDS52556.2

UniProtKB/TrEMBL

E9PZQ1, G3X9F7

Related

ENSMUSP00000070741.8, ENSMUST00000070631.15

Conserved Domains (3) summary

smart00490
Location:1252 → 1328

HELICc; helicase superfamily c-terminal domain

smart00487
Location:760 → 951

DEXDc; DEAD-like helicases superfamily

pfam00270
Location:766 → 920

DEAD; DEAD/DEAH box helicase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

62381155..62491278

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509393.3 → XP_006509456.1 probable ATP-dependent RNA helicase DDX60 isoform X1

UniProtKB/TrEMBL

E9PZQ1

Conserved Domains (2) summary

COG4581
Location:608 → 1318

Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

cd18025
Location:713 → 885

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
XM_017312697.3 → XP_017168186.1 probable ATP-dependent RNA helicase DDX60 isoform X5

Conserved Domains (1) summary

cd18025
Location:761 → 938

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
XM_006509396.3 → XP_006509459.1 probable ATP-dependent RNA helicase DDX60 isoform X6

Conserved Domains (1) summary

cd18025
Location:761 → 938

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
XM_011242214.3 → XP_011240516.1 probable ATP-dependent RNA helicase DDX60 isoform X3

Conserved Domains (1) summary

cd18025
Location:761 → 938

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
XM_036153914.1 → XP_036009807.1 probable ATP-dependent RNA helicase DDX60 isoform X4

Conserved Domains (1) summary

cd18025
Location:761 → 938

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
XM_017312698.3 → XP_017168187.1 probable ATP-dependent RNA helicase DDX60 isoform X7

Conserved Domains (1) summary

cl28899
Location:761 → 858

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_036153913.1 → XP_036009806.1 probable ATP-dependent RNA helicase DDX60 isoform X2

Conserved Domains (2) summary

COG4581
Location:356 → 967

Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

cd18025
Location:357 → 534

DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

RNA

XR_001778429.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081215.1: Suppressed sequence

Description

NM_001081215.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_144928.1: Suppressed sequence

Description

NM_144928.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.