Mlf1 myeloid leukemia factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mlf1provided by MGI
Official Full Name: myeloid leukemia factor 1provided by MGI
Primary source: MGI:MGI:1341819
See related: Ensembl:ENSMUSG00000048416 AllianceGenome:MGI:1341819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HLS7
Summary: Enables DNA binding activity. Involved in myeloid progenitor cell differentiation and transcription, DNA-templated. Located in several cellular components, including ciliary basal body; ciliary base; and non-motile cilium. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 137.0) and heart adult (RPKM 22.3) See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 30.91 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (67281430..67307333)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (67374097..67400000)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival.
Title: MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.
Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS) patients.
Title: Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
Title: Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.
Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
Title: Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in myeloid progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloid leukemia factor 1

Names: hematopoietic lineage switch 7; myelodysplasia-myeloid leukemia factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039543.2 → NP_001034632.1 myeloid leukemia factor 1 isoform a

See identical proteins and their annotated locations for NP_001034632.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK133448, BC027526

Consensus CDS

CCDS17395.1

UniProtKB/TrEMBL

Q8JZS2

Related

ENSMUSP00000058596.9, ENSMUST00000061322.10

Conserved Domains (1) summary

pfam10248
Location:27 → 217

Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
NM_010801.3 → NP_034931.2 myeloid leukemia factor 1 isoform b

See identical proteins and their annotated locations for NP_034931.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.

Source sequence(s)

AK133448, BC027526

Consensus CDS

CCDS17396.1

UniProtKB/Swiss-Prot

O70217, Q9QWV4

UniProtKB/TrEMBL

Q3V042

Related

ENSMUSP00000077072.6, ENSMUST00000077916.12

Conserved Domains (1) summary

pfam10248
Location:27 → 202

Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein