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    Cd302 CD302 antigen [ Mus musculus (house mouse) ]

    Gene ID: 66205, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cd302provided by MGI
    Official Full Name
    CD302 antigenprovided by MGI
    Primary source
    MGI:MGI:1913455
    See related
    Ensembl:ENSMUSG00000060703 AllianceGenome:MGI:1913455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110055L24Rik
    Summary
    Predicted to enable signaling receptor activity. Predicted to act upstream of or within phagocytosis. Predicted to be located in cell cortex and filopodium. Predicted to be active in external side of plasma membrane. Is expressed in ear; embryo; and forelimb bud. Orthologous to human CD302 (CD302 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 77.5), liver E18 (RPKM 52.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.1; 2 34.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60082337..60114828, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60251993..60284484, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-seq mESC enhancer starr_04605 Neighboring gene lactate dehydrogenase A, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5922 Neighboring gene STARR-seq mESC enhancer starr_04606 Neighboring gene STARR-seq mESC enhancer starr_04607 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene STARR-seq mESC enhancer starr_04608 Neighboring gene ribosomal protein L10A, pseudogene 4 Neighboring gene lymphocyte antigen 75 Neighboring gene predicted gene 13571 Neighboring gene STARR-seq mESC enhancer starr_04613 Neighboring gene predicted gene 13580

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. Lo TH, et al. J Immunol, 2016 Aug 1. PMID 27316686
    2. AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. Yasuda S, et al. Biochem J, 2011 Jul 15. PMID 21554246
    3. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. Kato M, et al. J Immunol, 2007 Nov 1. PMID 17947679
    4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies confirm a functional role for CD302 in myeloid dendritic cells migration.
      Title: Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
    2. hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration
      Title: The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD302 antigen
    Names
    C-type lectin domain family 13 member A
    type I transmembrane C-type lectin receptor DCL-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290660.1 → NP_001277589.1  CD302 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_001277589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA222439, AI116405, AK002812
      Consensus CDS
      CCDS71058.1
      UniProtKB/Swiss-Prot
      A2AW84, A2AW85, Q78KD8, Q9D0X7, Q9DCG2
      Related
      ENSMUSP00000074188.5, ENSMUST00000074606.11
      Conserved Domains (1) summary
      smart00034
      Location:22 → 151
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    2. NM_025422.4 → NP_079698.2  CD302 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_079698.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AA222439, AI116405, AK004267
      Consensus CDS
      CCDS16058.1
      UniProtKB/Swiss-Prot
      Q9DCG2
      Related
      ENSMUSP00000028356.9, ENSMUST00000028356.9
      Conserved Domains (1) summary
      smart00034
      Location:22 → 151
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      60082337..60114828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCG2.2 GenPept UniProtKB/Swiss-Prot:Q9DCG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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