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    Prodh2 proline dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361538, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Prodh2provided by RGD
    Official Full Name
    proline dehydrogenase 2provided by RGD
    Primary source
    RGD:1306761
    See related
    Ensembl:ENSRNOG00000057578 AllianceGenome:RGD:1306761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HYPDH
    Summary
    Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrion. Orthologous to human PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 644.5), Kidney (RPKM 494.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prodh2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94881000..94894609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85753558..85767165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88955125..88968501)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin Neighboring gene similar to Gene model 1082 Neighboring gene Rho GTPase activating protein 33 Neighboring gene uncharacterized LOC120097050

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. Summitt CB, et al. Biochem J, 2015 Mar 1. PMID 25697095, Free PMC Article
    2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH group of donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH group of donors ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyproline dehydrogenase
    Names
    probable proline dehydrogenase 2
    probable proline oxidase 2
    proline dehydrogenase (oxidase) 2
    proline oxidase-like protein
    NP_001033677.1
    XP_038937824.1
    XP_063122494.1
    XP_063122496.1
    XP_063122505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038588.1 → NP_001033677.1  hydroxyproline dehydrogenase

      See identical proteins and their annotated locations for NP_001033677.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158806
      UniProtKB/Swiss-Prot
      Q2V057
      UniProtKB/TrEMBL
      A0A0G2K5H0, B0BNG1
      Related
      ENSRNOP00000073423.2, ENSRNOT00000083550.2
      Conserved Domains (2) summary
      PLN02681
      Location:28 → 453
      PLN02681; proline dehydrogenase
      pfam01619
      Location:218 → 439
      Pro_dh; Proline dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94881000..94894609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266426.1 → XP_063122496.1  hydroxyproline dehydrogenase isoform X2

    2. XM_063266424.1 → XP_063122494.1  hydroxyproline dehydrogenase isoform X1

      UniProtKB/Swiss-Prot
      Q2V057

    3. XM_063266435.1 → XP_063122505.1  hydroxyproline dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A6J9X9

    4. XM_039081896.2 → XP_038937824.1  hydroxyproline dehydrogenase isoform X3

      Conserved Domains (1) summary
      cl40683
      Location:8 → 256
      Pro_dh; Proline dehydrogenase

    RNA

    1. XR_005487888.2 RNA Sequence

    2. XR_005487887.2 RNA Sequence

    3. XR_005487885.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2V057.1 GenPept UniProtKB/Swiss-Prot:Q2V057

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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