U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Prodh2 proline dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361538, updated on 6-Jun-2024

    Summary

    Official Symbol
    Prodh2provided by RGD
    Official Full Name
    proline dehydrogenase 2provided by RGD
    Primary source
    RGD:1306761
    See related
    Ensembl:ENSRNOG00000057578 AllianceGenome:RGD:1306761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HYPDH
    Summary
    Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrion. Orthologous to human PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 644.5), Kidney (RPKM 494.2) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prodh2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94881000..94894609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85753558..85767165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88955125..88968501)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin Neighboring gene similar to Gene model 1082 Neighboring gene Rho GTPase activating protein 33 Neighboring gene uncharacterized LOC120097050

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity, acting on the CH-NH group of donors ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on the CH-NH group of donors ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    hydroxyproline dehydrogenase
    Names
    probable proline dehydrogenase 2
    probable proline oxidase 2
    proline dehydrogenase (oxidase) 2
    proline oxidase-like protein
    NP_001033677.1
    XP_038937824.1
    XP_063122494.1
    XP_063122496.1
    XP_063122505.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038588.1NP_001033677.1  hydroxyproline dehydrogenase

      See identical proteins and their annotated locations for NP_001033677.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158806
      UniProtKB/Swiss-Prot
      Q2V057
      UniProtKB/TrEMBL
      A0A0G2K5H0, B0BNG1
      Related
      ENSRNOP00000073423.2, ENSRNOT00000083550.2
      Conserved Domains (2) summary
      PLN02681
      Location:28453
      PLN02681; proline dehydrogenase
      pfam01619
      Location:218439
      Pro_dh; Proline dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94881000..94894609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266426.1XP_063122496.1  hydroxyproline dehydrogenase isoform X2

    2. XM_063266424.1XP_063122494.1  hydroxyproline dehydrogenase isoform X1

      UniProtKB/Swiss-Prot
      Q2V057
    3. XM_063266435.1XP_063122505.1  hydroxyproline dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A6J9X9
    4. XM_039081896.2XP_038937824.1  hydroxyproline dehydrogenase isoform X3

      Conserved Domains (1) summary
      cl40683
      Location:8256
      Pro_dh; Proline dehydrogenase

    RNA

    1. XR_005487888.2 RNA Sequence

    2. XR_005487887.2 RNA Sequence

    3. XR_005487885.2 RNA Sequence