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    Ing1 inhibitor of growth family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 26356, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ing1provided by MGI
    Official Full Name
    inhibitor of growth family, member 1provided by MGI
    Primary source
    MGI:MGI:1349481
    See related
    Ensembl:ENSMUSG00000045969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mING; p33I; mING1h; p33Ing1; AA407184; AI875420; p37Ing1b; 2610028J21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.0), testis adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ing1 in Genome Data Viewer
    Location:
    8; 8 A1.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11605762..11613251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11555762..11563251)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (11556066..11563250)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NAD(P)HX dehydratase Neighboring gene cysteinyl-tRNA synthetase 2 (mitochondrial)(putative) Neighboring gene ankyrin repeat domain 10 Neighboring gene microRNA 7238 Neighboring gene RIKEN cDNA 1700016D06 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibitor of growth protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302451.1NP_001289380.1  inhibitor of growth protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an upstream alternate 5' terminal exon and uses an alternate in-frame splice site in the 5' coding region which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA407185, AK076482, AK141466, BX528243, CJ086997
      UniProtKB/TrEMBL
      Q3ULE3
      Conserved Domains (2) summary
      cd15584
      Location:176220
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      pfam12998
      Location:175
      ING; Inhibitor of growth proteins N-terminal histone-binding
    2. NM_001302457.1NP_001289386.1  inhibitor of growth protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001289386.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AK076482, AK141466, AK145553, BX528243
      Consensus CDS
      CCDS85499.1
      UniProtKB/Swiss-Prot
      Q9QXV3
      UniProtKB/TrEMBL
      Q3ULE3
      Related
      ENSMUSP00000147476.2, ENSMUST00000210740.2
      Conserved Domains (2) summary
      COG5034
      Location:37163
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15584
      Location:118162
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    3. NM_001302458.1NP_001289387.1  inhibitor of growth protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001289387.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC124475, AK076482, BX528243, CK624100
      Consensus CDS
      CCDS85499.1
      UniProtKB/Swiss-Prot
      Q9QXV3
      UniProtKB/TrEMBL
      Q3ULE3
      Related
      ENSMUSP00000148030.2, ENSMUST00000211007.2
      Conserved Domains (2) summary
      COG5034
      Location:37163
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15584
      Location:118162
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    4. NM_001302459.1NP_001289388.1  inhibitor of growth protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001289388.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses a downstream alternate 5' terminal exon, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC124475, AK035490, BX528243, BY063246
      Consensus CDS
      CCDS85499.1
      UniProtKB/Swiss-Prot
      Q9QXV3
      UniProtKB/TrEMBL
      Q3ULE3
      Related
      ENSMUSP00000147892.2, ENSMUST00000209565.2
      Conserved Domains (2) summary
      COG5034
      Location:37163
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15584
      Location:118162
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    5. NM_001302460.1NP_001289389.1  inhibitor of growth protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001289389.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC124475, AK035490, AK141466, BX528243, CJ086997, DV655694
      Consensus CDS
      CCDS85499.1
      UniProtKB/Swiss-Prot
      Q9QXV3
      UniProtKB/TrEMBL
      Q3ULE3
      Related
      ENSMUSP00000148248.2, ENSMUST00000209646.2
      Conserved Domains (2) summary
      COG5034
      Location:37163
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15584
      Location:118162
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    6. NM_011919.5NP_036049.2  inhibitor of growth protein 1 isoform 1

      See identical proteins and their annotated locations for NP_036049.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA407185, AC124475, AK076482, BX528243, CA320790
      Consensus CDS
      CCDS22097.1
      UniProtKB/Swiss-Prot
      Q9QXV3
      Related
      ENSMUSP00000062593.5, ENSMUST00000054399.6
      Conserved Domains (2) summary
      cd15584
      Location:212256
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      pfam12998
      Location:15111
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      11605762..11613251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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