Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    KRT83 keratin 83 [ Homo sapiens (human) ]

    Gene ID: 3889, updated on 8-Jul-2021

    Summary

    Official Symbol
    KRT83provided by HGNC
    Official Full Name
    keratin 83provided by HGNC
    Primary source
    HGNC:HGNC:6460
    See related
    Ensembl:ENSG00000170523 MIM:602765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB3; Hb-3; EKVP5; MNLIX; KRTHB3
    Summary
    The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KRT83 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52314301..52321398, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52708085..52715182, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 88 pseudogene Neighboring gene keratin 86 Neighboring gene keratin 81 Neighboring gene keratin 89 pseudogene Neighboring gene keratin 85

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141663

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type II cuticular Hb3
    Names
    K83
    hHb3
    hair keratin K2.10
    hard keratin, type II, 3
    keratin 83, type II
    keratin, hair, basic, 3
    type II hair keratin Hb3
    type-II keratin Kb23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008352.1 RefSeqGene

      Range
      5001..12098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1302

    mRNA and Protein(s)

    1. NM_002282.3NP_002273.3  keratin, type II cuticular Hb3

      See identical proteins and their annotated locations for NP_002273.3

      Status: REVIEWED

      Source sequence(s)
      AC121757, BC069546
      Consensus CDS
      CCDS8823.1
      UniProtKB/Swiss-Prot
      P78385
      Related
      ENSP00000293670.3, ENST00000293670.3
      Conserved Domains (4) summary
      pfam00038
      Location:110421
      Filament; Intermediate filament protein
      pfam16208
      Location:4107
      Keratin_2_head; Keratin type II head
      cl12013
      Location:235425
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:320388
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      52314301..52321398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center