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    Fastkd3 FAST kinase domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 69577, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fastkd3provided by MGI
    Official Full Name
    FAST kinase domains 3provided by MGI
    Primary source
    MGI:MGI:1916827
    See related
    Ensembl:ENSMUSG00000021532 AllianceGenome:MGI:1916827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310010B21Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing; mitochondrial cytochrome c oxidase assembly; and posttranscriptional regulation of gene expression. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTKD3 (FAST kinase domains 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.9), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B3; 13 35.55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (68730281..68740457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (68582167..68592338)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46386 Neighboring gene STARR-seq mESC enhancer starr_34921 Neighboring gene VISTA enhancer mm1330 Neighboring gene STARR-seq mESC enhancer starr_34924 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene predicted gene, 34903 Neighboring gene STARR-seq mESC enhancer starr_34926 Neighboring gene cilia and flagella associated protein 90 Neighboring gene adenylate cyclase 2 Neighboring gene STARR-seq mESC enhancer starr_34927 Neighboring gene STARR-seq mESC enhancer starr_34928 Neighboring gene farnesyl diphosphate synthetase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330423.1 → NP_001317352.1  FAST kinase domain-containing protein 3, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033189, CA560457, CJ265660, CT033781
      Consensus CDS
      CCDS36719.1
      UniProtKB/Swiss-Prot
      Q5XKD3, Q6P9N4, Q8BSN9, Q8CB52, Q8CCG7

    2. NM_027123.5 → NP_081399.3  FAST kinase domain-containing protein 3, mitochondrial

      See identical proteins and their annotated locations for NP_081399.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033189, CJ265660, CT033781
      Consensus CDS
      CCDS36719.1
      UniProtKB/Swiss-Prot
      Q5XKD3, Q6P9N4, Q8BSN9, Q8CB52, Q8CCG7
      Related
      ENSMUSP00000061737.9, ENSMUST00000051784.10
      Conserved Domains (3) summary
      smart00952
      Location:594 → 651
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:410 → 478
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:494 → 580
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. NR_138477.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK032530, AK033189, CJ265660, CT033781
      Related
      ENSMUST00000223319.2

    2. NR_138478.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon and uses alternate splice sites in the second exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AK033189, AW988524, CJ265660, CT033781
      Related
      ENSMUST00000222068.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      68730281..68740457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315595.2 → XP_017171084.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

      Conserved Domains (2) summary
      smart00952
      Location:381 → 438
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam08368
      Location:281 → 367
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_006517364.4 → XP_006517427.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      Conserved Domains (3) summary
      smart00952
      Location:631 → 688
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:447 → 515
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:531 → 617
      FAST_2; FAST kinase-like protein, subdomain 2

    3. XM_006517366.4 → XP_006517429.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006517429.1

      Conserved Domains (3) summary
      smart00952
      Location:397 → 454
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:213 → 281
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:297 → 383
      FAST_2; FAST kinase-like protein, subdomain 2

    4. XM_006517367.1 → XP_006517430.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006517430.1

      Conserved Domains (3) summary
      smart00952
      Location:397 → 454
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:213 → 281
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:297 → 383
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. XR_004938066.1 RNA Sequence

    2. XR_382449.4 RNA Sequence

    3. XR_003950475.1 RNA Sequence

    4. XR_004938067.1 RNA Sequence

    5. XR_003950476.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSN9.2 GenPept UniProtKB/Swiss-Prot:Q8BSN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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