Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh3bp5provided by MGI
Official Full Name: SH3-domain binding protein 5 (BTK-associated)provided by MGI
Primary source: MGI:MGI:1344391
See related: Ensembl:ENSMUSG00000021892 AllianceGenome:MGI:1344391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sab; SH3BP-5
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 46.1), CNS E14 (RPKM 37.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 19.11 cM; 14 B

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (31094571..31158056, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (31372614..31436100, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
Title: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
SAB expression levels determine the severity of JNK1-dependent liver injury
Title: Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury.
Title: c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis.
Title: Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
Title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs).
Title: SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
Title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE457740 (e-PCR)
- UniSTS:209012

AI606498 (e-PCR)
- UniSTS:164550

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	TAS Traceable Author Statement more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH3 domain-binding protein 5

Names: SH3 domain-binding protein that preferentially associates with BTK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347585.2 → NP_001334514.1 SH3 domain-binding protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC108416, AC154616

Consensus CDS

CCDS84108.1

UniProtKB/Swiss-Prot

Q3TTD6, Q8C903, Q8VCZ0, Q9Z131

Related

ENSMUSP00000098296.4, ENSMUST00000100730.10
NM_001404586.1 → NP_001391515.1 SH3 domain-binding protein 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC108416, AC154616
NM_001404587.1 → NP_001391516.1 SH3 domain-binding protein 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC108416, AC154616
NM_001404588.1 → NP_001391517.1 SH3 domain-binding protein 5 isoform 5

Status: VALIDATED

Source sequence(s)

AC108416, AC154616
NM_001404589.1 → NP_001391518.1 SH3 domain-binding protein 5 isoform 6

Status: VALIDATED

Source sequence(s)

AC108416, AC154616
NM_011894.4 → NP_036024.2 SH3 domain-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_036024.2

Status: VALIDATED

Source sequence(s)

AC108416, AC154616

Consensus CDS

CCDS36855.1

UniProtKB/Swiss-Prot

Q3TTD6, Q8C903, Q8VCZ0, Q9Z131

Related

ENSMUSP00000089517.5, ENSMUST00000091903.5

Conserved Domains (1) summary

pfam05276
Location:44 → 270

SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

31094571..31158056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247814.1 → XP_030103674.1 SH3 domain-binding protein 5 isoform X1

Conserved Domains (1) summary

pfam05276
Location:1 → 112

SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
XM_030247815.1 → XP_030103675.1 SH3 domain-binding protein 5 isoform X1

Conserved Domains (1) summary

pfam05276
Location:1 → 112

SH3BP5; SH3 domain-binding protein 5 (SH3BP5)