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    otx orthodenticle-related protein [ Strongylocentrotus purpuratus (purple sea urchin) ]

    Gene ID: 373400, updated on 14-Dec-2023

    Summary

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    Gene symbol
    otx
    Gene description
    orthodenticle-related protein
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Strongylocentrotus purpuratus
    Lineage
    Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae; Strongylocentrotus
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    102 current Spur_5.0 (GCF_000002235.5) Unplaced Scaffold NW_022145611.1 (20239836..20261988, complement)
    Build 3.1 previous assembly Spur_3.1 (GCF_000002235.3) Unplaced Scaffold NW_003577429.1 (417920..458294, complement)

    NW_022145611.1Genomic Context describing neighboring genes Neighboring gene goosecoid transcription factor Neighboring gene calmodulin Neighboring gene uncharacterized LOC115929504 Neighboring gene EH domain binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An otx cis-regulatory module: a key node in the sea urchin endomesoderm gene regulatory network. Yuh CH, et al. Dev Biol, 2004 May 15. PMID 15110718
    2. Correct Expression of spec2a in the sea urchin embryo requires both Otx and other cis-regulatory elements. Yuh CH, et al. Dev Biol, 2001 Apr 15. PMID 11401403
    3. Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus. Li X, et al. Dev Biol, 1997 Jul 15. PMID 9242422
    4. Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction. Chuang CK, et al. Dev Genet, 1996. PMID 8952065
    5. Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Mao CA, et al. Dev Biol, 1994 Sep. PMID 8088441

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. otx cis-regulatory module is a key node in the sea urchin endomesoderm gene regulatory network.
      Title: An otx cis-regulatory module: a key node in the sea urchin endomesoderm gene regulatory network.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein OTX
    Names
    orthodenticle homolog
    spOTX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032368.3 → NP_001027540.1  homeobox protein OTX isoform beta

      See identical proteins and their annotated locations for NP_001027540.1

      Status: PROVISIONAL

      Source sequence(s)
      AAGJ06000005
      UniProtKB/TrEMBL
      A0A7M6UUE2
      Conserved Domains (1) summary
      pfam00046
      Location:59 → 111
      Homeobox; Homeobox domain

    2. NM_001032369.2 → NP_001027541.1  homeobox protein OTX isoform beta

      See identical proteins and their annotated locations for NP_001027541.1

      Status: PROVISIONAL

      Source sequence(s)
      AAGJ02120737
      UniProtKB/TrEMBL
      A0A7M6UUE2
      Conserved Domains (1) summary
      pfam00046
      Location:59 → 111
      Homeobox; Homeobox domain

    3. NM_214588.4 → NP_999753.2  homeobox protein OTX isoform alpha

      Status: PROVISIONAL

      Source sequence(s)
      AAGJ06000005
      UniProtKB/Swiss-Prot
      Q26417
      UniProtKB/TrEMBL
      A0A7M6UHL8
      Conserved Domains (1) summary
      pfam00046
      Location:135 → 187
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Strongylocentrotus purpuratus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Spur_5.0 Primary Assembly

    Genomic

    1. NW_022145611.1 Reference Spur_5.0 Primary Assembly

      Range
      20239836..20261988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q26417.1 GenPept UniProtKB/Swiss-Prot:Q26417

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