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    Fam118a family with sequence similarity 118, member A [ Mus musculus (house mouse) ]

    Gene ID: 73225, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam118aprovided by MGI
    Official Full Name
    family with sequence similarity 118, member Aprovided by MGI
    Primary source
    MGI:MGI:1920475
    See related
    Ensembl:ENSMUSG00000022434 AllianceGenome:MGI:1920475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in cerebral cortex and cerebral cortex marginal layer. Orthologous to human FAM118A (family with sequence similarity 118 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.6), bladder adult (RPKM 8.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E2; 15 40.25 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84921263..85001781)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85037062..85117580)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene predicted gene, 52194 Neighboring gene uroplakin 3A Neighboring gene STARR-seq mESC enhancer starr_39377 Neighboring gene structural maintenance of chromosomes 1B Neighboring gene ribosomal protein L23A pseudogene Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene predicted gene, 19277

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • 3110048E14Rik, C230014M12Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM118A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356616.1 → NP_001343545.1  protein FAM118A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Consensus CDS
      CCDS27717.1
      UniProtKB/Swiss-Prot
      Q3UP97, Q8C4H6, Q8C5E1, Q91YN1
      Related
      ENSMUSP00000154985.2, ENSMUST00000229203.2
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    2. NM_001356617.1 → NP_001343546.1  protein FAM118A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    3. NM_001356618.1 → NP_001343547.1  protein FAM118A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    4. NM_001378838.1 → NP_001365767.1  protein FAM118A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    5. NM_001378839.1 → NP_001365768.1  protein FAM118A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    6. NM_001378840.1 → NP_001365769.1  protein FAM118A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:149 → 254
      SIR2_2; SIR2-like domain

    7. NM_001378841.1 → NP_001365770.1  protein FAM118A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:149 → 254
      SIR2_2; SIR2-like domain

    8. NM_001378842.1 → NP_001365771.1  protein FAM118A isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    9. NM_001378843.1 → NP_001365772.1  protein FAM118A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL772308
      Conserved Domains (1) summary
      pfam13289
      Location:44 → 149
      SIR2_2; SIR2-like domain

    10. NM_133750.4 → NP_598511.1  protein FAM118A isoform 2

      See identical proteins and their annotated locations for NP_598511.1

      Status: VALIDATED

      Source sequence(s)
      BC066174, CJ084461
      Consensus CDS
      CCDS27717.1
      UniProtKB/Swiss-Prot
      Q3UP97, Q8C4H6, Q8C5E1, Q91YN1
      Related
      ENSMUSP00000023069.8, ENSMUST00000023069.9
      Conserved Domains (1) summary
      pfam13289
      Location:142 → 247
      SIR2_2; SIR2-like domain

    RNA

    1. NR_166139.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772308

    2. NR_166140.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772308

    3. NR_166141.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772308

    4. NR_166142.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772308

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      84921263..85001781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177067.3: Suppressed sequence

      Description
      NM_177067.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YN1.1 GenPept UniProtKB/Swiss-Prot:Q91YN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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