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    Osbpl6 oxysterol binding protein-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 99031, updated on 16-Oct-2021

    Summary

    Official Symbol
    Osbpl6provided by MGI
    Official Full Name
    oxysterol binding protein-like 6provided by MGI
    Primary source
    MGI:MGI:2139014
    See related
    Ensembl:ENSMUSG00000042359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORP-6; AI596402; mKIAA4128; 1110062M20Rik
    Expression
    Broad expression in kidney adult (RPKM 4.2), lung adult (RPKM 3.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Osbpl6 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76236848..76430991)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76406504..76600647)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76244595..76438704)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator Neighboring gene pejvakin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4128, MGC30542

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oxysterol-binding protein-related protein 6
    Names
    OSBP-related protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290733.1NP_001277662.1  oxysterol-binding protein-related protein 6 isoform b

      See identical proteins and their annotated locations for NP_001277662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AI597353, AK044411, AL928867, BY704583, CJ104457
      Consensus CDS
      CCDS71078.1
      UniProtKB/Swiss-Prot
      Q8BXR9
      Related
      ENSMUSP00000107560.2, ENSMUST00000111929.8
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:595943
      Oxysterol_BP; Oxysterol-binding protein
    2. NM_001290734.1NP_001277663.1  oxysterol-binding protein-related protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AI597353, AK037703, AL928867, BY704583, CJ104457
      Consensus CDS
      CCDS71079.1
      UniProtKB/Swiss-Prot
      Q8BXR9
      Related
      ENSMUSP00000107561.3, ENSMUST00000111930.9
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:564912
      Oxysterol_BP; Oxysterol-binding protein
    3. NM_001290735.1NP_001277664.1  oxysterol-binding protein-related protein 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' terminal exons, and it lacks several 3' exons and thus differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AL928905, CJ098947
      Related
      ENSMUST00000128034.2
    4. NM_145525.3NP_663500.2  oxysterol-binding protein-related protein 6 isoform a

      See identical proteins and their annotated locations for NP_663500.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI597353, AK044411, AL928867, AL928905, BY704583, CJ104457
      Consensus CDS
      CCDS16158.1
      UniProtKB/Swiss-Prot
      Q8BXR9
      UniProtKB/TrEMBL
      F8WIZ7
      Related
      ENSMUSP00000077123.5, ENSMUST00000077972.11
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76236848..76430991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239862.3XP_011238164.1  oxysterol-binding protein-related protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011238164.1

      UniProtKB/Swiss-Prot
      Q8BXR9
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:595943
      Oxysterol_BP; Oxysterol-binding protein
    2. XM_036162747.1XP_036018640.1  oxysterol-binding protein-related protein 6 isoform X6

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:559907
      Oxysterol_BP; Oxysterol-binding protein
    3. XM_011239864.3XP_011238166.1  oxysterol-binding protein-related protein 6 isoform X3

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:578926
      Oxysterol_BP; Oxysterol-binding protein
    4. XM_011239866.3XP_011238168.1  oxysterol-binding protein-related protein 6 isoform X5

      See identical proteins and their annotated locations for XP_011238168.1

      Related
      ENSMUSP00000139363.2, ENSMUST00000184442.2
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:570918
      Oxysterol_BP; Oxysterol-binding protein
    5. XM_036162748.1XP_036018641.1  oxysterol-binding protein-related protein 6 isoform X9

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:534882
      Oxysterol_BP; Oxysterol-binding protein
    6. XM_011239865.3XP_011238167.1  oxysterol-binding protein-related protein 6 isoform X4

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:572920
      Oxysterol_BP; Oxysterol-binding protein
    7. XM_011239867.3XP_011238169.1  oxysterol-binding protein-related protein 6 isoform X7

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:547895
      Oxysterol_BP; Oxysterol-binding protein
    8. XM_011239868.3XP_011238170.1  oxysterol-binding protein-related protein 6 isoform X8

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:539887
      Oxysterol_BP; Oxysterol-binding protein
    9. XM_036162749.1XP_036018642.1  oxysterol-binding protein-related protein 6 isoform X10

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:503851
      Oxysterol_BP; Oxysterol-binding protein
    10. XM_011239869.2XP_011238171.1  oxysterol-binding protein-related protein 6 isoform X11

      Conserved Domains (1) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    11. XM_036162751.1XP_036018644.1  oxysterol-binding protein-related protein 6 isoform X12

      Conserved Domains (1) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    12. XM_036162753.1XP_036018646.1  oxysterol-binding protein-related protein 6 isoform X14

      Conserved Domains (1) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    13. XM_036162752.1XP_036018645.1  oxysterol-binding protein-related protein 6 isoform X13

      Conserved Domains (1) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    14. XM_036162754.1XP_036018647.1  oxysterol-binding protein-related protein 6 isoform X15

      Conserved Domains (1) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    15. XM_011239859.2XP_011238161.1  oxysterol-binding protein-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011238161.1

      UniProtKB/TrEMBL
      F8WIZ7
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein
    16. XM_036162750.1XP_036018643.1  oxysterol-binding protein-related protein 6 isoform X10

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:503851
      Oxysterol_BP; Oxysterol-binding protein
    17. XM_011239860.2XP_011238162.1  oxysterol-binding protein-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011238162.1

      UniProtKB/TrEMBL
      F8WIZ7
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein
    18. XM_036162746.1XP_036018639.1  oxysterol-binding protein-related protein 6 isoform X1

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein
    19. XM_030252270.1XP_030108130.1  oxysterol-binding protein-related protein 6 isoform X1

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein
    20. XM_030252269.1XP_030108129.1  oxysterol-binding protein-related protein 6 isoform X1

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603951
      Oxysterol_BP; Oxysterol-binding protein
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