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    Agk acylglycerol kinase [ Mus musculus (house mouse) ]

    Gene ID: 69923, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Agkprovided by MGI
    Official Full Name
    acylglycerol kinaseprovided by MGI
    Primary source
    MGI:MGI:1917173
    See related
    Ensembl:ENSMUSG00000029916 AllianceGenome:MGI:1917173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mulk; 2610037M15Rik; 6720408I04Rik
    Summary
    Enables acylglycerol kinase activity; ceramide kinase activity; and diacylglycerol kinase activity. Acts upstream of or within ceramide biosynthetic process and lipid phosphorylation. Located in membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.1), CNS E14 (RPKM 4.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B1; 6 18.82 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40302010..40378723)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40325076..40397570)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15673 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene transmembrane protein 178B Neighboring gene STARR-seq mESC enhancer starr_15674 Neighboring gene STARR-seq mESC enhancer starr_15675 Neighboring gene STARR-seq mESC enhancer starr_15676 Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene DENN domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_15685 Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene single-stranded DNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of AGK in thrombocytopoiesis and possible therapeutic strategies. Jiang H, et al. Blood, 2020 Jul 2. PMID 32202634
    2. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells. Hu Z, et al. Cell Metab, 2019 Aug 6. PMID 31204281
    3. MuLK, a eukaryotic multi-substrate lipid kinase. Waggoner DW, et al. J Biol Chem, 2004 Sep 10. PMID 15252046
    4. Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Wang X, et al. Mol Cancer, 2014 May 8. PMID 24886245, Free PMC Article
    5. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. Van Overloop H, et al. J Lipid Res, 2006 Feb. PMID 16269826

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of AGK in thrombocytopoiesis and possible therapeutic strategies.
      Title: The role of AGK in thrombocytopoiesis and possible therapeutic strategies.
    2. AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1.
      Title: Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroceramide kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acylglycerol kinase, mitochondrial
    Names
    multi-substrate lipid kinase
    multiple substrate lipid kinase
    NP_076027.1
    XP_006506634.1
    XP_011239760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023538.2 → NP_076027.1  acylglycerol kinase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_076027.1

      Status: VALIDATED

      Source sequence(s)
      AC153728
      Consensus CDS
      CCDS20027.1
      UniProtKB/Swiss-Prot
      Q9D087, Q9ESW4
      Related
      ENSMUSP00000031977.9, ENSMUST00000031977.12
      Conserved Domains (1) summary
      pfam00781
      Location:62 → 195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      40302010..40378723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241458.3 → XP_011239760.1  acylglycerol kinase, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00781
      Location:62 → 182
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. XM_006506571.4 → XP_006506634.1  acylglycerol kinase, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam00781
      Location:1 → 102
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESW4.1 GenPept UniProtKB/Swiss-Prot:Q9ESW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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