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    Ap2b1 adaptor related protein complex 2 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140670, updated on 25-Jan-2022

    Summary

    Symbol
    Ap2b1provided by RGD
    Full Name
    adaptor related protein complex 2 subunit beta 1provided by RGD
    Primary source
    RGD:71048
    See related
    Ensembl:ENSRNOG00000061543 AllianceGenome:RGD:71048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; negative regulation of neuron death; and positive regulation of endocytosis. Part of clathrin coat. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in Testes (RPKM 391.0), Brain (RPKM 322.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ap2b1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68099397..68205023)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70516462..70621973)

    Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095157 Neighboring gene 40S ribosomal protein S27-like Neighboring gene Z30 small nucleolar RNA Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin coat assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of AP-type membrane coat adaptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of clathrin adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin coat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AP-2 complex subunit beta
    Names
    AP-1 complex subunit beta-1-like
    AP-2 complex subunit beta-like
    AP105B
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptor protein complex AP-2 subunit beta
    adaptor-related protein complex 2 subunit beta
    adaptor-related protein complex 2, beta 1 subunit
    beta-2-adaptin
    beta-adaptin
    beta2-adaptin
    clathrin assembly protein complex 2 beta large chain
    plasma membrane adaptor HA2/AP2 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080583.2NP_542150.1  AP-2 complex subunit beta

      See identical proteins and their annotated locations for NP_542150.1

      Status: PROVISIONAL

      Source sequence(s)
      JACYVU010000220
      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Related
      ENSRNOP00000070905.1, ENSRNOT00000088198.2
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

      Range
      68099397..68205023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767937.3XP_008766159.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008766159.1

      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. XM_017596973.2XP_017452462.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    3. XM_008767936.3XP_008766158.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008766158.1

      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    4. XM_008767938.2XP_008766160.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008766160.1

      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Related
      ENSRNOP00000073619.2, ENSRNOT00000090446.2
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    5. XM_008767939.3XP_008766161.1  AP-2 complex subunit beta isoform X2

      See identical proteins and their annotated locations for XP_008766161.1

      UniProtKB/Swiss-Prot
      P62944
      Related
      ENSRNOP00000084537.1, ENSRNOT00000117903.1
      Conserved Domains (4) summary
      smart00809
      Location:717817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    6. XM_008767935.3XP_008766157.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008766157.1

      UniProtKB/Swiss-Prot
      P62944
      UniProtKB/TrEMBL
      Q3ZB97
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
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