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    Scn7a sodium voltage-gated channel alpha subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64155, updated on 30-Sep-2021

    Summary

    Official Symbol
    Scn7aprovided by RGD
    Official Full Name
    sodium voltage-gated channel alpha subunit 7provided by RGD
    Primary source
    RGD:61922
    See related
    EnsemblRapid:ENSRNOG00000029342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Na-G; Scn6a
    Summary
    glial Na-channel alpha subunit [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 437.9), Heart (RPKM 196.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Scn7a in Genome Data Viewer
    Location:
    3q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (51335841..51438308, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (52775779..52877365, complement)

    Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350387 Neighboring gene sodium voltage-gated channel alpha subunit 9 Neighboring gene histone deacetylase 1-like Neighboring gene similar to 40S ribosomal protein S3 Neighboring gene 60S ribosomal protein L9-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium channel protein type 7 subunit alpha
    Names
    sodium channel voltage-gated type VI alpha polypeptide
    sodium channel, voltage-gated, type 6, alpha polypeptide
    sodium channel, voltage-gated, type VII, alpha subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388508.1NP_001375437.1  sodium channel protein type 7 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      JACYVU010000115
      Related
      ENSRNOP00000044385.5, ENSRNOT00000041096.5
      Conserved Domains (3) summary
      cd13433
      Location:11941245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:9321203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742926
      Na_trans_assoc; Sodium ion transport-associated

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

      Range
      51335841..51438308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105781.1XP_038961709.1  sodium channel protein type 7 subunit alpha isoform X3

      Conserved Domains (3) summary
      cd13433
      Location:11581209
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:504738
      Ion_trans; Ion transport protein
      pfam06512
      Location:742926
      Na_trans_assoc; Sodium ion transport-associated
    2. XM_039105780.1XP_038961708.1  sodium channel protein type 7 subunit alpha isoform X2

      Conserved Domains (3) summary
      cd13433
      Location:11941244
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:9321199
      Ion_trans; Ion transport protein
      pfam06512
      Location:742926
      Na_trans_assoc; Sodium ion transport-associated
    3. XM_039105778.1XP_038961706.1  sodium channel protein type 7 subunit alpha isoform X1

      Conserved Domains (3) summary
      cd13433
      Location:11941245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:9321203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742926
      Na_trans_assoc; Sodium ion transport-associated
    4. XM_039105779.1XP_038961707.1  sodium channel protein type 7 subunit alpha isoform X1

      Conserved Domains (3) summary
      cd13433
      Location:11941245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:9321203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742926
      Na_trans_assoc; Sodium ion transport-associated

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031686.1: Suppressed sequence

      Description
      NM_031686.1: This RefSeq was removed because there is insufficient support for the protein.
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