Itga8 integrin alpha 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga8provided by MGI
Official Full Name: integrin alpha 8provided by MGI
Primary source: MGI:MGI:109442
See related: Ensembl:ENSMUSG00000026768 AllianceGenome:MGI:109442
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]
Expression: Biased expression in lung adult (RPKM 16.4), bladder adult (RPKM 4.7) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 9.12 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (12111443..12306755, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (12106632..12301985, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of integrin alpha8 in murine model of lung fibrosis
Title: Role of integrin alpha8 in murine model of lung fibrosis.
Itga8-/- renal mesangial cells showed reduced phagocytosis of matrix-coated beads and apoptotic cells compared to WT renal mesangial cells.
Title: Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.
alpha8 Integrin is expressed in functional placental compartments among its ligands, OPN and/or FN, across species. Although this may point to a regulatory role in trophoblast function, our data from alpha8 integrin-deficient mice indicated only mild placental pathology.
Title: Integrin α8 Is Abundant in Human, Rat, and Mouse Trophoblasts.
Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8
Title: Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.
Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.
Title: α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism.
Itga8 seems to attenuate tubulointerstitial fibrosis in unilateral ureteral obstruction not via regulation of cell turnover, but via regulation of TGF-beta signalling, fibroblast activation and/or immune cell infiltration
Title: Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.
Fibrillin-1 and alpha8 integrin interact, and thus, regulate mesangial cell adhesion and migration.
Title: Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.
Alpha 8 integrin expression is strongly induced in a mouse model of renal fibrosis.
Title: Tubulointerstitial de novo expression of the α8 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy?
The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome.
Title: Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
Lack of alpha8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.
Title: Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI447669 (e-PCR)
- UniSTS:164145

MARC_50801-50802:1130354928:1 (e-PCR)
- UniSTS:477514

D2Mit116 (e-PCR), detects polymorphism
- UniSTS:128975

D2Mit118 (e-PCR), detects polymorphism
- UniSTS:128977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic spine membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001309.4 → NP_001001309.1 integrin alpha-8 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001001309.1

Status: REVIEWED

Source sequence(s)

AL845313

Consensus CDS

CCDS15689.1

UniProtKB/Swiss-Prot

A2ARA8, O70304, Q3UXV8, Q8BRG3, Q8C0H7

Related

ENSMUSP00000028106.5, ENSMUST00000028106.11

Conserved Domains (3) summary

smart00191
Location:382 → 436

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1034 → 1048

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:482 → 933

Integrin_alpha2; Integrin alpha
NM_001408100.1 → NP_001395029.1 integrin alpha-8 isoform 2 preproprotein

Status: REVIEWED

Source sequence(s)

AL845313
NM_001408101.1 → NP_001395030.1 integrin alpha-8 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AL845313
NM_001408102.1 → NP_001395031.1 integrin alpha-8 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AL845313

RNA

NR_138462.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AK033007, AK044910, AL845313, BC137793, BQ175493

Related

ENSMUST00000172791.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

12111443..12306755 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497476.4 → XP_006497539.1 integrin alpha-8 isoform X2

Conserved Domains (2) summary

pfam00357
Location:592 → 606

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:23 → 474

Integrin_alpha2; Integrin alpha