Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Papss1provided by RGD
Official Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by RGD
Primary source: RGD:1308081
See related: Ensembl:ENSRNOG00000011311 AllianceGenome:RGD:1308081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable adenylylsulfate kinase activity; protein homodimerization activity; and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 344.7), Brain (RPKM 246.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (222646103..222788475)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (220040343..220114399)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (236605695..236680772)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129187 (e-PCR)
- UniSTS:212495

G46408 (e-PCR)
- UniSTS:107210

Papss1 (e-PCR), detects polymorphism
- UniSTS:144121

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylylsulfate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylylsulfate kinase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sulfate adenylyltransferase (ATP) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sulfate assimilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate assimilation	IEA Inferred from Electronic Annotation more info
involved_in sulfate assimilation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

NP_001381988.1

EC 2.7.7.4

XP_063137732.1

EC 2.7.7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395059.1 → NP_001381988.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2K0L0, B2RYI8

Related

ENSRNOP00000071489.2, ENSRNOT00000085301.2

Conserved Domains (2) summary

cd00517
Location:254 → 617

ATPS; ATP-sulfurylase

pfam01583
Location:51 → 205

APS_kinase; Adenylylsulphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

222646103..222788475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281662.1 → XP_063137732.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K0L0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106471.1: Suppressed sequence

Description

NM_001106471.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.