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    Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult [ Mus musculus (house mouse) ]

    Gene ID: 17882, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Myh2provided by MGI
    Official Full Name
    myosin, heavy polypeptide 2, skeletal muscle, adultprovided by MGI
    Primary source
    MGI:MGI:1339710
    See related
    Ensembl:ENSMUSG00000033196 AllianceGenome:MGI:1339710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MHC2A; Myh2a; Myhs-f; Myhsf1; Myhs-f1; MyHC-IIa
    Summary
    Acts upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to activity. Located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in inclusion body myositis and proximal myopathy and ophthalmoplegia. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 15.2), kidney adult (RPKM 2.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 40.59 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67061853..67088343)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67171027..67197517)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31285 Neighboring gene predicted gene, 53683 Neighboring gene STARR-seq mESC enhancer starr_29795 Neighboring gene STARR-seq mESC enhancer starr_29796 Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Substrate curvature sensing through Myosin IIa upregulates early osteogenesis. Ozdemir T, et al. Integr Biol (Camb), 2013 Nov. PMID 24104522
    2. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. Jacobelli J, et al. PLoS One, 2013. PMID 24069389, Free PMC Article
    3. Comparing the effect of uniaxial cyclic mechanical stimulation and chemical factors on myogenin and Myh2 expression in mouse embryonic and bone marrow derived mesenchymal stem cells. Tannaz NA, et al. Mol Cell Biomech, 2014 Mar. PMID 25330622
    4. Analysis of the local organization and dynamics of cellular actin networks. Luo W, et al. J Cell Biol, 2013 Sep 30. PMID 24081490, Free PMC Article
    5. Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids. Iresjö BM, et al. J Transl Med, 2012 Nov 28. PMID 23190566, Free PMC Article

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
      Title: Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly.
    2. Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
      Title: Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture.
    3. myosin IIa is essential for B cell development, proliferation, and antibody responses.
      Title: Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation.
    4. nonmuscle myosin 2A replacement with myosin 2C1 permits gastrulation but not placenta vascular development in mice
      Title: Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice.
    5. Inhibition of myosin IIA decreases annexin 1 nuclear translocation in oxygen-glucose deprivation.
      Title: Following OGD/R, annexin 1 nuclear translocation and subsequent induction of apoptosis in neurons are assisted by myosin IIA in a TRPM7 kinase-dependent manner.
    6. Myh2 expression was significantly higher in ESCs-mechanical group than that in the same group of MSCs.
      Title: Comparing the effect of uniaxial cyclic mechanical stimulation and chemical factors on myogenin and Myh2 expression in mouse embryonic and bone marrow derived mesenchymal stem cells.
    7. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
      Title: Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
    8. Myosin IIa has a role in upregulating early osteogenesis
      Title: Substrate curvature sensing through Myosin IIa upregulates early osteogenesis.
    9. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice
      Title: Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids.
    10. Increase of CYP1A1-mRNA was due to nonmuscle myosin II inhibition.
      Title: Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin-mediated cell contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myosin-2
    Names
    myosin heavy chain 2A
    skeletal muscle myosin heavy chain II-a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039545.2 → NP_001034634.2  myosin-2

      See identical proteins and their annotated locations for NP_001034634.2

      Status: VALIDATED

      Source sequence(s)
      AL596129
      Consensus CDS
      CCDS24854.2
      UniProtKB/TrEMBL
      B2RWX0, G3UW82
      Related
      ENSMUSP00000129544.2, ENSMUST00000170159.8
      Conserved Domains (7) summary
      cl22853
      Location:100 → 773
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:88 → 773
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:853 → 1930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00459
      Location:1302 → 1414
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:1673 → 1770
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:968 → 1101
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67061853..67088343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144961.1: Suppressed sequence

      Description
      NM_144961.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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