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    Chpt1 choline phosphotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 212862, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Chpt1provided by MGI
    Official Full Name
    choline phosphotransferase 1provided by MGI
    Primary source
    MGI:MGI:2384841
    See related
    Ensembl:ENSMUSG00000060002 AllianceGenome:MGI:2384841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within phosphatidylcholine biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and retina. Orthologous to human CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 37.3), kidney adult (RPKM 34.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chpt1 in Genome Data Viewer
    Location:
    10 C1; 10 43.93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88305376..88339855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88469513..88503970, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2332 Neighboring gene STARR-positive B cell enhancer ABC_E11453 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene STARR-positive B cell enhancer ABC_E5162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:87872706-87873007 Neighboring gene STARR-positive B cell enhancer ABC_E2333 Neighboring gene STARR-positive B cell enhancer ABC_E3906 Neighboring gene synaptonemal complex protein 3 Neighboring gene STARR-seq mESC enhancer starr_27496 Neighboring gene myosin binding protein C, slow-type Neighboring gene STARR-seq mESC enhancer starr_27498 Neighboring gene STARR-positive B cell enhancer ABC_E6897 Neighboring gene STARR-seq mESC enhancer starr_27500 Neighboring gene STARR-seq mESC enhancer starr_27501 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered mouse cholinephosphotransferase gene expression in kidneys of type 2 diabetic KK/TA mouse. Gohda T, et al. Metabolism, 2004 Jul. PMID 15254874
    2. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
    3. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
    4. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. Gao L, et al. J Clin Invest, 2015 Jul 1. PMID 26098214, Free PMC Article
    5. Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Imbard A, et al. Sci Rep, 2021 Oct 26. PMID 34702858, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cholinephosphotransferase 1
    Names
    diabetic nephropathy-associated gene transcript 1
    diacylglycerol cholinephosphotransferase 1
    NP_001140162.1
    NP_659056.3
    XP_006513517.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146690.1 → NP_001140162.1  cholinephosphotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AW823530, BE137041, BE650891, BY341208, CJ177670, EL958096
      Consensus CDS
      CCDS48665.1
      UniProtKB/TrEMBL
      D3YU39
      Related
      ENSMUSP00000112708.2, ENSMUST00000117440.8
      Conserved Domains (1) summary
      cl00453
      Location:25 → 337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. NM_144807.3 → NP_659056.3  cholinephosphotransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_659056.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 3' coding region and 3' UTR versus variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC125486, AK032497, CJ177670
      Consensus CDS
      CCDS24112.1
      UniProtKB/Swiss-Prot
      Q6SXV1, Q8C025, Q8K0H2, Q91W91
      Related
      ENSMUSP00000020253.9, ENSMUST00000020253.15
      Conserved Domains (1) summary
      cl00453
      Location:25 → 337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. NR_027477.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 3' coding region, compared to variant 1. Uncertainty about the protein-coding capacity of the transcript exists because the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW823530, BE650891, BY341208, CJ177670, EL958096

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      88305376..88339855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513454.3 → XP_006513517.1  cholinephosphotransferase 1 isoform X1

      Conserved Domains (1) summary
      cl00453
      Location:25 → 213
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. XR_004936148.1 RNA Sequence

    2. XR_003948646.2 RNA Sequence

    3. XR_003948645.2 RNA Sequence

    4. XR_003948644.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C025.1 GenPept UniProtKB/Swiss-Prot:Q8C025

    Gene LinkOut

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