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    Chgb chromogranin B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24259, updated on 2-May-2024

    Summary

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    Official Symbol
    Chgbprovided by RGD
    Official Full Name
    chromogranin Bprovided by RGD
    Primary source
    RGD:2339
    See related
    Ensembl:ENSRNOG00000021269 AllianceGenome:RGD:2339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Located in secretory granule. Orthologous to human CHGB (chromogranin B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 1136.2) and Brain (RPKM 450.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140496712..140510057)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120043824..120057169)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125428050..125441601)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552951 Neighboring gene shieldin complex subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene minichromosome maintenance 8 homologous recombination repair factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. Bearrows SC, et al. J Cell Sci, 2019 Jul 1. PMID 31182646, Free PMC Article
    2. A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture media. Taylor SW, et al. J Proteome Res, 2008 Feb. PMID 18181560
    3. Nucleotide sequence and cellular distribution of rat chromogranin B (secretogranin I) mRNA in the neuroendocrine system. Forss-Petter S, et al. J Mol Neurosci, 1989. PMID 2641278
    4. Chromogranin-B, a putative precursor of eight novel rat glucagonoma peptides through processing at mono-, di-, or tribasic residues. Nielsen E, et al. Endocrinology, 1991 Dec. PMID 1954895
    5. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. Zhang K, et al. J Neurochem, 2014 Apr. PMID 24266713, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CgB is necessary for efficient trafficking of secretory proteins into the budding granule, which impacts the availability of insulin-containing secretory granules for exocytic release.
      Title: Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells.
    2. Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation.
      Title: A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.
    3. When released extra-cellulary, CHGB proteolytic fragments exert a feedback effect to inhibit catecholamine secretion.
      Title: Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms.
    4. Chrombacin is a 60 residue anti-microbial neuroendocrine peptide that includes an unusual sulfotyrosine-, phosphoserine-containing motif.
      Title: A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture media.
    5. Stimulation with a secretagogue mixture induced parallel release of insulin and chromogranin B from pancreatic beta cells.
      Title: Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.
    6. CGB is a novel regulator of cardiomyocyte InsP(3)/Ca(2+)-dependent signaling, nuclear factor kappaB activity, and brain natriuretic peptide production
      Title: Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes.
    7. CGB was localized in the nucleus; transcription control role of CGB in the nucleus
      Title: Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control.
    8. Chromogranin B has a role in secretory granule biogenesis
      Title: Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156676

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretogranin-1
    Names
    Chromogranin B, parathyroid secretory protein
    cgB
    chromogranin B (secretogranin 1)
    glucagonoma peptide
    secretogranin-I
    sgI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012526.2 → NP_036658.2  secretogranin-1 precursor

      See identical proteins and their annotated locations for NP_036658.2

      Status: VALIDATED

      Source sequence(s)
      BC128743, CB705583
      UniProtKB/Swiss-Prot
      A1A5N9, O35314, Q9QVG8, Q9QVH1
      UniProtKB/TrEMBL
      A0A8L2QFU5, A6HQH2
      Related
      ENSRNOP00000028892.4, ENSRNOT00000028892.5
      Conserved Domains (1) summary
      pfam01271
      Location:26 → 672
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140496712..140510057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235072.5 → XP_006235134.1  secretogranin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AW29, A0A8L2QFU5, A6HQH2
      Related
      ENSRNOP00000097178.1
      Conserved Domains (1) summary
      pfam01271
      Location:44 → 690
      Granin; Granin (chromogranin or secretogranin)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35314.2 GenPept UniProtKB/Swiss-Prot:O35314

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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