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    Nek3 NIMA (never in mitosis gene a)-related expressed kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 23954, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Nek3provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 3provided by MGI
    Primary source
    MGI:MGI:1344371
    See related
    Ensembl:ENSMUSG00000031478 AllianceGenome:MGI:1344371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including neuron projection morphogenesis; protein phosphorylation; and regulation of tubulin deacetylation. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including brain; genitourinary system; intestine; and spleen. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.5), CNS E11.5 (RPKM 2.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nek3 in Genome Data Viewer
    Location:
    8 A2; 8 11.07 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22618299..22657009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22128283..22166997, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2858 Neighboring gene STARR-seq mESC enhancer starr_20897 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene STARR-seq mESC enhancer starr_20898 Neighboring gene predicted gene, 57529 Neighboring gene STARR-seq mESC enhancer starr_20899 Neighboring gene STARR-seq mESC enhancer starr_20900 Neighboring gene cytoskeleton associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_20901 Neighboring gene predicted gene, 29878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. Chang J, et al. J Cell Sci, 2009 Jul 1. PMID 19509051, Free PMC Article
    2. Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. Tanaka K, et al. J Biol Chem, 1999 May 7. PMID 10224116
    3. The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. Guipponi M, et al. Hum Genet, 2001 Dec. PMID 11810268
    4. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Chen A, et al. Gene, 1999 Jun 24. PMID 10393247
    5. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Nek3 influences neuronal morphogenesis and polarity through effects on microtubules.
      Title: The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek3
    Names
    NIMA-related expressed kinase 3
    never in mitosis A-related kinase 3
    nimA-related protein kinase 3
    NP_001156419.1
    NP_001411132.1
    NP_035978.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162947.2 → NP_001156419.1  serine/threonine-protein kinase Nek3 isoform 1

      See identical proteins and their annotated locations for NP_001156419.1

      Status: VALIDATED

      Source sequence(s)
      AC117665
      Consensus CDS
      CCDS52519.1
      UniProtKB/Swiss-Prot
      E9QLM2, Q9R0A5, Q9Z0X9
      UniProtKB/TrEMBL
      Q99K72
      Related
      ENSMUSP00000136876.2, ENSMUST00000178324.2
      Conserved Domains (1) summary
      cl21453
      Location:3 → 255
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001424203.1 → NP_001411132.1  serine/threonine-protein kinase Nek3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117665

    3. NM_011848.5 → NP_035978.2  serine/threonine-protein kinase Nek3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117665
      Consensus CDS
      CCDS22169.1
      UniProtKB/TrEMBL
      F8WGD4, Q99K72
      Related
      ENSMUSP00000033865.10, ENSMUST00000033865.16
      Conserved Domains (2) summary
      smart00220
      Location:4 → 250
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 255
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_188143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117665

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22618299..22657009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_378785.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0A5.2 GenPept UniProtKB/Swiss-Prot:Q9R0A5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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