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    Zkscan16 zinc finger with KRAB and SCAN domains 16 [ Mus musculus (house mouse) ]

    Gene ID: 100041581, updated on 8-Mar-2024

    Summary

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    Official Symbol
    Zkscan16provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 16provided by MGI
    Primary source
    MGI:MGI:3510405
    See related
    Ensembl:ENSMUSG00000038630 AllianceGenome:MGI:3510405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp483; XM_143800
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF483 (zinc finger protein 483). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 7.1), frontal lobe adult (RPKM 6.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zkscan16 in Genome Data Viewer
    Location:
    4 B3; 4 32.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58943568..58962624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58943568..58962624)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene prostaglandin reductase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 483

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099323.3 → NP_001092793.1  zinc finger protein 483

      See identical proteins and their annotated locations for NP_001092793.1

      Status: VALIDATED

      Source sequence(s)
      AK032125, AL805972
      Consensus CDS
      CCDS38771.1
      UniProtKB/TrEMBL
      A2ALW2
      Related
      ENSMUSP00000103178.2, ENSMUST00000107554.2
      Conserved Domains (5) summary
      smart00349
      Location:170 → 223
      KRAB; krueppel associated box
      COG5048
      Location:537 → 725
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK07219
      Location:383 → 489
      PRK07219; DNA topoisomerase I; Validated
      sd00017
      Location:513 → 533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 132
      SCAN; SCAN domain

    2. NM_001355408.1 → NP_001342337.1  zinc finger protein 483

      Status: VALIDATED

      Source sequence(s)
      AK032125, AL805972
      Consensus CDS
      CCDS38771.1
      UniProtKB/TrEMBL
      A2ALW2
      Conserved Domains (5) summary
      smart00349
      Location:170 → 223
      KRAB; krueppel associated box
      COG5048
      Location:537 → 725
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK07219
      Location:383 → 489
      PRK07219; DNA topoisomerase I; Validated
      sd00017
      Location:513 → 533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 132
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      58943568..58962624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537508.2 → XP_006537571.1  zinc finger protein 483 isoform X1

      See identical proteins and their annotated locations for XP_006537571.1

      UniProtKB/TrEMBL
      A2ALW2
      Conserved Domains (5) summary
      smart00349
      Location:170 → 223
      KRAB; krueppel associated box
      COG5048
      Location:537 → 725
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK07219
      Location:383 → 489
      PRK07219; DNA topoisomerase I; Validated
      sd00017
      Location:513 → 533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 132
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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