Defb11 defensin beta 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defb11provided by MGI
Official Full Name: defensin beta 11provided by MGI
Primary source: MGI:MGI:2179197
See related: Ensembl:ENSMUSG00000045337 AllianceGenome:MGI:2179197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BD-11; Defb8
Summary: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 48.6), testis adult (RPKM 9.6) and 1 other tissue See more
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Genomic context

Location:: 8 A2; 8 10.59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22395383..22396448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (21905374..21906432, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The epididymis-specific expression pattern of the beta-defensin isoform mBD-11 has been characterized.
Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-defensin 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.