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    Ramp2 receptor (calcitonin) activity modifying protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 54409, updated on 26-Oct-2021

    Summary

    Official Symbol
    Ramp2provided by MGI
    Official Full Name
    receptor (calcitonin) activity modifying protein 2provided by MGI
    Primary source
    MGI:MGI:1859650
    See related
    Ensembl:ENSMUSG00000001240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in lung adult (RPKM 313.3), subcutaneous fat pad adult (RPKM 94.5) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ramp2 in Genome Data Viewer
    Location:
    11 D; 11 64.47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101137160..101139076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101246334..101248250)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101107648..101109564)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 1 Neighboring gene chemokine (C-C motif) receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene vacuolar protein sorting 25 Neighboring gene WNK lysine deficient protein kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adrenomedullin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adrenomedullin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to amylin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adherens junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenomedullin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amylin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basement membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of adrenomedullin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of amylin receptor complex 2 ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor activity-modifying protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019444.2NP_062317.1  receptor activity-modifying protein 2 precursor

      See identical proteins and their annotated locations for NP_062317.1

      Status: VALIDATED

      Source sequence(s)
      AK003810, BC051201, BY312723
      Consensus CDS
      CCDS25457.1
      UniProtKB/Swiss-Prot
      Q9WUP0
      Related
      ENSMUSP00000122072.2, ENSMUST00000129680.8
      Conserved Domains (1) summary
      pfam04901
      Location:83186
      RAMP; Receptor activity modifying family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101137160..101139076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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