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    CG4991 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32695, updated on 10-May-2024

    Summary

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    Official Symbol
    CG4991provided by FlyBase
    Primary source
    FLYBASE:FBgn0030817
    Locus tag
    Dmel_CG4991
    See related
    AllianceGenome:FB:FBgn0030817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT15971; Dmel\CG4991
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Is expressed in adult abdomen; adult head; adult thorax; and organism. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG4991 in Genome Data Viewer
    Location:
    15E2-15E3; 1-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17091854..17104562)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16985887..16998595)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 3B Neighboring gene uncharacterized protein Neighboring gene meiotic 218

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of heritable symbionts on maternally-derived embryo transcripts. Mateos M, et al. Sci Rep, 2019 Jun 20. PMID 31222094, Free PMC Article
    2. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
    3. Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo. Barckmann B, et al. Cell Rep, 2015 Aug 18. PMID 26257181, Free PMC Article
    4. Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, et al. Neurobiol Dis, 2017 Nov. PMID 28237316
    5. A post-ingestive amino acid sensor promotes food consumption in Drosophila. Yang Z, et al. Cell Res, 2018 Oct. PMID 30209352, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4991-PA
    CG4991-PB
    CG4991-PD
    CG4991-PE
    CG4991-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17091854..17104562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144742.2 → NP_001138214.2  uncharacterized protein Dmel_CG4991, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138214.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z9, E9LFH1, E9LFH3, E9LFH4, Q9VX83
      Conserved Domains (2) summary
      COG0814
      Location:47 → 451
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_167555.3 → NP_728048.1  uncharacterized protein Dmel_CG4991, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z9, E9LFH1, E9LFH3, E9LFH4, Q9VX83
      Related
      FBpp0074158
      Conserved Domains (2) summary
      COG0814
      Location:47 → 451
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001272710.2 → NP_001259639.1  uncharacterized protein Dmel_CG4991, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z9, E9LFH1, E9LFH3, E9LFH4, Q9VX83
      Conserved Domains (2) summary
      COG0814
      Location:47 → 451
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001272709.2 → NP_001259638.1  uncharacterized protein Dmel_CG4991, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9LFH1, E9LFH3, E9LFH4, M9PHT8
      Conserved Domains (2) summary
      COG0814
      Location:84 → 488
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:82 → 489
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_132964.3 → NP_573192.1  uncharacterized protein Dmel_CG4991, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z9, E9LFH1, E9LFH3, E9LFH4, Q9VX83
      Related
      FBpp0074159
      Conserved Domains (2) summary
      COG0814
      Location:47 → 451
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHT8 M9PHT8
    Q9VX83 Q9VX83

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