PTK2B protein tyrosine kinase 2 beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTK2Bprovided by HGNC
Official Full Name: protein tyrosine kinase 2 betaprovided by HGNC
Primary source: HGNC:HGNC:9612
See related: Ensembl:ENSG00000120899 MIM:601212; AllianceGenome:HGNC:9612
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 29.2), bone marrow (RPKM 29.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p21.2

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (27310506..27459391)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (27583138..27736745)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (27168995..27316908)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease.
Title: Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease.
Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1 Pathway Modulation.
Title: Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.
The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.
Title: The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.
The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.
Title: The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.
PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis.
Title: PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis.
Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression.
Title: Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression.
Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
Title: Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma.
Title: High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma.
Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Title: Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes.
Title: Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes.

Submit: New GeneRIF Correction See all GeneRIFs (181)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV/tuberculosis coinfection upregulates PTK2B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only)	PubMed
Knockdown of protein tyrosine kinase 2 beta (PTK2B) by siRNA enhances HIV-1 infectivity in Jurkat cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SMS2 is involved in HIV-1 gp120-induced phosphorylation and activation of PYK2 and polymerization of F-actin	PubMed
	env	Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2	PubMed
	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	HIV-1 gp120-induced Pyk2 activation mediated by intracellular Ca2+ release is required for HIV-1 gp120-mediated Rac-1 activation and membrane fusion	PubMed
Nef	nef	HIV-1 Nef expression in human T cells upregulates the levels of RAFTK activity through the SDF-1alpha signaling pathway	PubMed
Tat	tat	HIV-1 Tat C induces phosphorylation of PTK2B in a dose-dependent manner in human brain microvascular endothelial cells	PubMed
	tat	HIV-1 Tat stimulates the tyrosine phosphorylation of RAFTK and its association with paxillin, an effect mediated by the basic (amino acids 46-60) and RGD-containing (amino acids 65-80) domains of Tat and linked to AIDS-related Kaposi's sarcoma	PubMed
reverse transcriptase	gag-pol	Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT	PubMed
	gag-pol	HIV-1 RT is identified to have a physical interaction with protein tyrosine kinase 2 beta (PTK2B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HSC25C022 (e-PCR)
- UniSTS:24321

SHGC-147423 (e-PCR)
- UniSTS:172802

RH69058 (e-PCR)
- UniSTS:20264

D8S465 (e-PCR)
- UniSTS:62536

SHGC-154215 (e-PCR)
- UniSTS:184758

G59208 (e-PCR)
- UniSTS:136381

RH12429 (e-PCR)
- UniSTS:4805

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in activation of Janus kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular defense response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in marginal zone B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein-containing complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macrophage chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to cation stress	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in apical dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	TAS Traceable Author Statement more info	PubMed
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein-tyrosine kinase 2-beta

Names: CAK-beta; FADK 2; PTK2B protein tyrosine kinase 2 beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein kinase B; related adhesion focal tyrosine kinase

NP_004094.3

EC 2.7.10.2

NP_775266.1

EC 2.7.10.2

NP_775267.1

EC 2.7.10.2

NP_775268.1

EC 2.7.10.2

XP_005273504.1

EC 2.7.10.2

XP_011542743.1

EC 2.7.10.2

XP_011542744.1

EC 2.7.10.2

XP_016868703.1

EC 2.7.10.2

XP_016868704.1

EC 2.7.10.2

XP_016868705.1

EC 2.7.10.2

XP_047277487.1

EC 2.7.10.2

XP_047277488.1

EC 2.7.10.2

XP_047277489.1

EC 2.7.10.2

XP_047277490.1

EC 2.7.10.2

XP_047277491.1

EC 2.7.10.2

XP_047277492.1

EC 2.7.10.2

XP_047277493.1

EC 2.7.10.2

XP_047277494.1

EC 2.7.10.2

XP_047277495.1

EC 2.7.10.2

XP_047277496.1

EC 2.7.10.2

XP_047277497.1

EC 2.7.10.2

XP_047277498.1

EC 2.7.10.2

XP_047277499.1

EC 2.7.10.2

XP_047277500.1

EC 2.7.10.2

XP_047277501.1

EC 2.7.10.2

XP_047277502.1

EC 2.7.10.2

XP_047277503.1

EC 2.7.10.2

XP_047277504.1

EC 2.7.10.2

XP_047277505.1

EC 2.7.10.2

XP_047277506.1

EC 2.7.10.2

XP_047277507.1

EC 2.7.10.2

XP_047277508.1

EC 2.7.10.2

XP_047277509.1

EC 2.7.10.2

XP_047277511.1

EC 2.7.10.2

XP_047277512.1

EC 2.7.10.2

XP_047277513.1

EC 2.7.10.2

XP_047277514.1

EC 2.7.10.2

XP_047277515.1

EC 2.7.10.2

XP_047277516.1

EC 2.7.10.2

XP_047277517.1

EC 2.7.10.2

XP_047277518.1

EC 2.7.10.2

XP_047277519.1

EC 2.7.10.2

XP_047277520.1

EC 2.7.10.2

XP_054216027.1

EC 2.7.10.2

XP_054216028.1

EC 2.7.10.2

XP_054216029.1

EC 2.7.10.2

XP_054216030.1

EC 2.7.10.2

XP_054216031.1

EC 2.7.10.2

XP_054216032.1

EC 2.7.10.2

XP_054216033.1

EC 2.7.10.2

XP_054216034.1

EC 2.7.10.2

XP_054216035.1

EC 2.7.10.2

XP_054216036.1

EC 2.7.10.2

XP_054216037.1

EC 2.7.10.2

XP_054216038.1

EC 2.7.10.2

XP_054216039.1

EC 2.7.10.2

XP_054216040.1

EC 2.7.10.2

XP_054216041.1

EC 2.7.10.2

XP_054216042.1

EC 2.7.10.2

XP_054216043.1

EC 2.7.10.2

XP_054216044.1

EC 2.7.10.2

XP_054216045.1

EC 2.7.10.2

XP_054216046.1

EC 2.7.10.2

XP_054216047.1

EC 2.7.10.2

XP_054216048.1

EC 2.7.10.2

XP_054216049.1

EC 2.7.10.2

XP_054216050.1

EC 2.7.10.2

XP_054216051.1

EC 2.7.10.2

XP_054216052.1

EC 2.7.10.2

XP_054216053.1

EC 2.7.10.2

XP_054216054.1

EC 2.7.10.2

XP_054216055.1

EC 2.7.10.2

XP_054216056.1

EC 2.7.10.2

XP_054216057.1

EC 2.7.10.2

XP_054216058.1

EC 2.7.10.2

XP_054216059.1

EC 2.7.10.2

XP_054216060.1

EC 2.7.10.2

XP_054216061.1

EC 2.7.10.2

XP_054216062.1

EC 2.7.10.2

XP_054216063.1

EC 2.7.10.2

XP_054216064.1

EC 2.7.10.2

XP_054216065.1

EC 2.7.10.2

XP_054216066.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029510.2 RefSeqGene

Range

19071..152905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004103.4 → NP_004094.3 protein-tyrosine kinase 2-beta isoform a

See identical proteins and their annotated locations for NP_004094.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC036651, U33284, U43522

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
NM_173174.3 → NP_775266.1 protein-tyrosine kinase 2-beta isoform a

See identical proteins and their annotated locations for NP_775266.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AC124649, AL120380, BC036651, BM712234, BQ009032, U33284

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Related

ENSP00000380638.1, ENST00000397501.5

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
NM_173175.2 → NP_775267.1 protein-tyrosine kinase 2-beta isoform b

See identical proteins and their annotated locations for NP_775267.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC036651, U33284

Consensus CDS

CCDS6058.1

UniProtKB/Swiss-Prot

Q14289

Related

ENSP00000391995.2, ENST00000420218.3

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:830 → 959

Focal_AT; Focal adhesion targeting region
NM_173176.3 → NP_775268.1 protein-tyrosine kinase 2-beta isoform a

See identical proteins and their annotated locations for NP_775268.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC042599, U33284

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Related

ENSP00000332816.6, ENST00000346049.10

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

27310506..27459391

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421544.1 → XP_047277500.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421545.1 → XP_047277501.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421552.1 → XP_047277508.1 protein-tyrosine kinase 2-beta isoform X3
XM_047421543.1 → XP_047277499.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421532.1 → XP_047277488.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421533.1 → XP_047277489.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421557.1 → XP_047277513.1 protein-tyrosine kinase 2-beta isoform X5
XM_047421539.1 → XP_047277495.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421537.1 → XP_047277493.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421538.1 → XP_047277494.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421551.1 → XP_047277507.1 protein-tyrosine kinase 2-beta isoform X3
XM_047421547.1 → XP_047277503.1 protein-tyrosine kinase 2-beta isoform X2
XM_047421555.1 → XP_047277511.1 protein-tyrosine kinase 2-beta isoform X5
XM_047421549.1 → XP_047277505.1 protein-tyrosine kinase 2-beta isoform X3
XM_047421563.1 → XP_047277519.1 protein-tyrosine kinase 2-beta isoform X7
XM_047421531.1 → XP_047277487.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421548.1 → XP_047277504.1 protein-tyrosine kinase 2-beta isoform X2
XM_047421556.1 → XP_047277512.1 protein-tyrosine kinase 2-beta isoform X5
XM_011544442.4 → XP_011542744.1 protein-tyrosine kinase 2-beta isoform X3

Conserved Domains (6) summary

cd05056
Location:405 → 674

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:412 → 666

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 355

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:859 → 988

Focal_AT; Focal adhesion targeting region
XM_017013216.3 → XP_016868705.1 protein-tyrosine kinase 2-beta isoform X4
XM_047421546.1 → XP_047277502.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421536.1 → XP_047277492.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421550.1 → XP_047277506.1 protein-tyrosine kinase 2-beta isoform X3
XM_047421535.1 → XP_047277491.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421558.1 → XP_047277514.1 protein-tyrosine kinase 2-beta isoform X5
XM_047421534.1 → XP_047277490.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421540.1 → XP_047277496.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_017013214.2 → XP_016868703.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
XM_011544441.3 → XP_011542743.1 protein-tyrosine kinase 2-beta isoform X1

See identical proteins and their annotated locations for XP_011542743.1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
XM_047421561.1 → XP_047277517.1 protein-tyrosine kinase 2-beta isoform X5

Related

ENSP00000427931.1, ENST00000517339.5
XM_017013215.2 → XP_016868704.1 protein-tyrosine kinase 2-beta isoform X3

Conserved Domains (6) summary

cd05056
Location:405 → 674

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:412 → 666

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 355

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:859 → 988

Focal_AT; Focal adhesion targeting region
XM_047421541.1 → XP_047277497.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4
XM_047421560.1 → XP_047277516.1 protein-tyrosine kinase 2-beta isoform X5
XM_005273447.5 → XP_005273504.1 protein-tyrosine kinase 2-beta isoform X1

See identical proteins and their annotated locations for XP_005273504.1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
XM_047421559.1 → XP_047277515.1 protein-tyrosine kinase 2-beta isoform X5
XM_047421562.1 → XP_047277518.1 protein-tyrosine kinase 2-beta isoform X6
XM_047421553.1 → XP_047277509.1 protein-tyrosine kinase 2-beta isoform X3
XM_047421564.1 → XP_047277520.1 protein-tyrosine kinase 2-beta isoform X7
XM_047421542.1 → XP_047277498.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/Swiss-Prot

D3DST0, Q13475, Q14289, Q14290, Q16709, Q6PID4