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    KRT4 keratin 4 [ Homo sapiens (human) ]

    Gene ID: 3851, updated on 23-Nov-2021

    Summary

    Official Symbol
    KRT4provided by HGNC
    Official Full Name
    keratin 4provided by HGNC
    Primary source
    HGNC:HGNC:6441
    See related
    Ensembl:ENSG00000170477 MIM:123940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K4; CK4; CK-4; CYK4; WSN1
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward esophagus (RPKM 10134.3) See more
    Orthologs
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    Genomic context

    See KRT4 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52806549..52814116, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53200333..53207900, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 76 Neighboring gene keratin 3 Neighboring gene keratin 79 Neighboring gene keratin 78

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of keratin 4 (KRT4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: KRT79

    Homology

    Clone Names

    • FLJ31692

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 4
    Names
    cytokeratin 4
    keratin 4, type II
    type-II keratin Kb4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007380.1 RefSeqGene

      Range
      5436..13003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002272.4NP_002263.3  keratin, type II cytoskeletal 4

      Status: REVIEWED

      Source sequence(s)
      AC107016, AK299400, AW082111, DR423040
      Consensus CDS
      CCDS41787.2
      UniProtKB/TrEMBL
      B4DRS2
      Related
      ENSP00000448220.1, ENST00000551956.2
      Conserved Domains (2) summary
      pfam00038
      Location:136449
      Filament; Intermediate filament protein
      pfam16208
      Location:14133
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      52806549..52814116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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