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    Popdc2 popeye domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360718, updated on 3-Apr-2024

    Summary

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    Symbol
    Popdc2provided by RGD
    Full Name
    popeye domain containing 2provided by RGD
    Primary source
    RGD:735226
    See related
    Ensembl:ENSRNOG00000058752 AllianceGenome:RGD:735226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including heart development; skeletal muscle tissue development; and striated muscle cell differentiation. Predicted to act upstream of or within regulation of heart rate and sinoatrial node cell development. Predicted to be located in membrane. Predicted to be active in sarcolemma. Orthologous to human POPDC2 (popeye domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 242.5), Muscle (RPKM 54.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75850068..75897094, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62351843..62398688, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64915041..64954704, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene phospholipase A1 member A Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene cilia and flagella associated protein 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Popdc gene family in the rat: molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes. Parnes D, et al. Biochim Biophys Acta, 2007 Sep-Oct. PMID 17662479
    2. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. Holt I, et al. BMC Mol Cell Biol, 2020 Dec 1. PMID 33261556, Free PMC Article
    3. POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking. Schindler RF, et al. J Clin Invest, 2016 Jan. PMID 26642364, Free PMC Article
    4. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. Froese A, et al. J Clin Invest, 2012 Mar. PMID 22354168, Free PMC Article
    5. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Andrée B, et al. Dev Biol, 2000 Jul 15. PMID 10882522

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
      Title: An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72601

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sinoatrial node cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in striated muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    popeye domain-containing protein 2
    Names
    popeye domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199113.1 → NP_954544.1  popeye domain-containing protein 2

      See identical proteins and their annotated locations for NP_954544.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061876
      UniProtKB/TrEMBL
      A0A8I6GG90, Q6P722
      Related
      ENSRNOP00000071721.1, ENSRNOT00000087892.2
      Conserved Domains (1) summary
      pfam04831
      Location:26 → 251
      Popeye; Popeye protein conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75850068..75897094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270640.1 → XP_063126710.1  popeye domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q6P722

    2. XM_008768734.4 → XP_008766956.1  popeye domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008766956.1

      UniProtKB/TrEMBL
      A6IR71
      Conserved Domains (1) summary
      pfam04831
      Location:26 → 308
      Popeye; Popeye protein conserved region

    3. XM_008768733.4 → XP_008766955.1  popeye domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008766955.1

      UniProtKB/TrEMBL
      A6IR71
      Conserved Domains (1) summary
      pfam04831
      Location:26 → 308
      Popeye; Popeye protein conserved region

    4. XM_017598027.3 → XP_017453516.1  popeye domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IR71
      Conserved Domains (1) summary
      pfam04831
      Location:26 → 308
      Popeye; Popeye protein conserved region

    5. XM_063270639.1 → XP_063126709.1  popeye domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q6P722

    6. XM_039088491.2 → XP_038944419.1  popeye domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam04831
      Location:25 → 202
      Popeye; Popeye protein conserved region

    RNA

    1. XR_005491039.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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