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    Ephx2 epoxide hydrolase 2, cytoplasmic [ Mus musculus (house mouse) ]

    Gene ID: 13850, updated on 16-Oct-2021

    Summary

    Official Symbol
    Ephx2provided by MGI
    Official Full Name
    epoxide hydrolase 2, cytoplasmicprovided by MGI
    Primary source
    MGI:MGI:99500
    See related
    Ensembl:ENSMUSG00000022040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CEH; SEH; sEP; Eph2
    Expression
    Biased expression in liver adult (RPKM 79.4), ovary adult (RPKM 75.1) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ephx2 in Genome Data Viewer
    Location:
    14 D1; 14 34.36 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66321821..66361971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66084372..66124522, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66703214..66743337, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene gulonolactone (L-) oxidase Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene predicted gene, 52098

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epoxide hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysophosphatidic acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within aromatic compound catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stilbene catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional epoxide hydrolase 2
    Names
    cytosolic epoxide hydrolase
    epoxide hydratase
    epoxide hydrolase 2C
    soluble epoxide hydrolase
    NP_001258331.1
    NP_001258332.1
    NP_001258350.1
    NP_031966.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271402.1NP_001258331.1  bifunctional epoxide hydrolase 2 isoform b

      See identical proteins and their annotated locations for NP_001258331.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at the 5' exon, differs in the 5' UTR, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC126272, AK002415
      Conserved Domains (4) summary
      cd01427
      Location:58150
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01509
      Location:1150
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      pfam00561
      Location:204477
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:186326
      Abhydrolase; alpha/beta hydrolases
    2. NM_001271403.1NP_001258332.1  bifunctional epoxide hydrolase 2 isoform c precursor

      See identical proteins and their annotated locations for NP_001258332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 15601917. The encoded isoform (c) contains a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC126272, AY098585
      Consensus CDS
      CCDS88694.1
      UniProtKB/Swiss-Prot
      P34914
      Related
      ENSMUSP00000153161.2, ENSMUST00000224698.2
      Conserved Domains (4) summary
      cd01427
      Location:93185
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01509
      Location:49185
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      pfam00561
      Location:239512
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:221361
      Abhydrolase; alpha/beta hydrolases
    3. NM_001271421.1NP_001258350.1  bifunctional epoxide hydrolase 2 isoform d

      See identical proteins and their annotated locations for NP_001258350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 17900570. The encoded isoform (d) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AC126272, EF597241
      Consensus CDS
      CCDS88693.1
      UniProtKB/TrEMBL
      A8JYK8
      Related
      ENSMUSP00000152894.2, ENSMUST00000225309.2
      Conserved Domains (4) summary
      cd01427
      Location:45137
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01509
      Location:1137
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      pfam00561
      Location:191464
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:173313
      Abhydrolase; alpha/beta hydrolases
    4. NM_007940.4NP_031966.2  bifunctional epoxide hydrolase 2 isoform a

      See identical proteins and their annotated locations for NP_031966.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC126272, AK142714
      Consensus CDS
      CCDS27218.1
      UniProtKB/Swiss-Prot
      P34914
      UniProtKB/TrEMBL
      Q3UQ71
      Related
      ENSMUSP00000069209.2, ENSMUST00000070515.2
      Conserved Domains (2) summary
      cd02603
      Location:3214
      HAD_sEH-N_like; N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive
      pfam00561
      Location:257530
      Abhydrolase_1; alpha/beta hydrolase fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66321821..66361971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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