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    Ubb ubiquitin B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192255, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ubbprovided by RGD
    Official Full Name
    ubiquitin Bprovided by RGD
    Primary source
    RGD:621562
    See related
    AllianceGenome:RGD:621562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tag and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process; positive regulation of protein monoubiquitination; and protein ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; energy homeostasis; and meiosis I. Predicted to be located in mitochondrion; neuron projection; and neuronal cell body. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBB (ubiquitin B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 9372.8), Brain (RPKM 6561.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubb in Genome Data Viewer
    Location:
    10q23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47746923..47748628)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47247630..47249335)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48880231..48881896)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene centromere protein V Neighboring gene transmembrane p24 trafficking protein 4, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene transient receptor potential cation channel, subfamily V, member 2 Neighboring gene small nucleolar RNA, C/D box 49B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expressions of ubiquitin and hsp70 following focal ischaemia in rat brain. Noga M, et al. Neuroreport, 1997 Mar 24. PMID 9175121
    2. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Ryu KY, et al. Proc Natl Acad Sci U S A, 2008 Mar 11. PMID 18299572, Free PMC Article
    3. Polyubiquitin is a new phenotypic marker of contractile vascular smooth muscle cells. Adam PJ, et al. Cardiovasc Res, 1997 Feb. PMID 9074707
    4. Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. Zhang Y, et al. J Cereb Blood Flow Metab, 2010 Mar. PMID 19844237, Free PMC Article
    5. Differential feeding-related regulation of ubiquitin and calbindin9kDa in rat duodenum. Hubbard MJ, et al. Biochim Biophys Acta, 1994 Jul 6. PMID 8031840

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mn(2+)-induced SNAT3 protein degradation and the dysregulation of Gln homeostasis in primary astrocyte cultures proceeds through the ubiquitin-mediated proteolytic system
      Title: Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system.
    2. We conclude that activation of caspase-3 might be upstream of UBB(+1) formation and that excessive UBB(+1) could bind to beta secretase
      Title: Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat pad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyubiquitin-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409092.1 → NP_001396021.1  polyubiquitin-B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P0CG51

    2. NM_138895.3 → NP_620250.3  polyubiquitin-B precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P0CG51

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      47746923..47748628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG51.1 GenPept UniProtKB/Swiss-Prot:P0CG51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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