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    Pbp pheromone binding protein [ Bombyx mori (domestic silkworm) ]

    Gene ID: 693050, updated on 9-Feb-2024

    Summary

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    Gene symbol
    Pbp
    Gene description
    pheromone binding protein
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
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    Genomic context

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    See Pbp in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 19 NC_085125.1 (476297..478059, complement)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 19 NC_051376.1 (1743378..1745140)

    Chromosome 19 - NC_085125.1Genomic Context describing neighboring genes Neighboring gene protein prickle Neighboring gene uncharacterized LOC134200616 Neighboring gene pheromone binding protein 2 Neighboring gene general odorant binding protein 2 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori. Shiota Y, et al. Sci Rep, 2018 Sep 10. PMID 30202026, Free PMC Article
    2. Dynamic conformational equilibria in the physiological function of the Bombyx mori pheromone-binding protein. Michel E, et al. J Mol Biol, 2011 May 20. PMID 21396939
    3. Deciphering the selectivity of Bombyx mori pheromone binding protein for bombykol over bombykal: a theoretical approach. Charlier L, et al. Chemphyschem, 2008 Dec 22. PMID 19025731
    4. Molecular switches for pheromone release from a moth pheromone-binding protein. Xu W, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18503757
    5. Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Sandler BH, et al. Chem Biol, 2000 Feb. PMID 10662696

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study results indicate that Bombyx mori pheromone binding protein-1 (BmPBP1) plays a crucial role in enhancing the sensitivity, but not the selectivity, of sex pheromone detection in silkmoths.
      Title: In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori.
    2. The C-terminal tetradecapeptide of pheromone-binding protein has dual roles in reversible pheromone binding and transport, governing dynamic equilibria between two locally different protein conformations at acidic pH.
      Title: Dynamic conformational equilibria in the physiological function of the Bombyx mori pheromone-binding protein.
    3. selectivity of Bombyx mori pheromone binding protein for bombykol over bombykal is quantified by the binding free-energy difference
      Title: Deciphering the selectivity of Bombyx mori pheromone binding protein for bombykol over bombykal: a theoretical approach.
    4. C-terminal segment and a flexible loop of Pbp are involved in the release of pheromones to membrane-bound receptors.
      Title: Molecular switches for pheromone release from a moth pheromone-binding protein.
    5. We have identified two novel genes, which encode candidate pheromone binding proteins PBPs (BmorPBP2, BmorPBP3).
      Title: Candidate pheromone binding proteins of the silkmoth Bombyx mori.
    6. both distinct pheromone receptors and Pheromone binding proteins play an important role in insect pheromone recognition
      Title: A pheromone-binding protein mediates the bombykol-induced activation of a pheromone receptor in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables odorant binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pheromone-binding protein
    Names
    pheromone binding protein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044029.1 → NP_001037494.1  pheromone-binding protein precursor

      See identical proteins and their annotated locations for NP_001037494.1

      Status: VALIDATED

      Source sequence(s)
      X94987
      UniProtKB/Swiss-Prot
      P34174, Q17235
      UniProtKB/TrEMBL
      S5MI56
      Conserved Domains (1) summary
      smart00708
      Location:37 → 144
      PhBP; Insect pheromone/odorant binding protein domains

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085125.1 Reference ASM3026992v2 Primary Assembly

      Range
      476297..478059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34174.2 GenPept UniProtKB/Swiss-Prot:P34174

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